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严重急性呼吸综合征冠状病毒2型奥密克戎变种:为何全球各界应予以重视?

SARS-CoV-2 Omicron variant: Why global communities should take it seriously?

作者信息

Rahmani Shayan, Rezaei Nima

机构信息

Department of Medical Virology, Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Division of Medical Research, Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.

出版信息

Immun Inflamm Dis. 2022 May;10(5):e618. doi: 10.1002/iid3.618.

Abstract

INTRODUCTION

In November 26th, 2021 a new strain of SARS-CoV-2 was designated by the World Health Organization as a variant of concern and named Omicron. The news broadcasted a global wave of panic and anxiety while many, like 2 years ago, were making themselves ready for the holiday season. After almost a month of its designation, countries from all 6 continents have been reported Omicron from their genomic sequences. This triggered an international alarm about a new era in the Covid-19 pandemic, where despite the vast amount of vaccinations, a surge in new cases and hospitalizations are reported from all over the world.

METHODS

Scientific literature published from November 26, 2021 to March 21, 2022 have been searched and retrieved by using "SARS-COV-2", "Omicron", "B.1.1.529", "Covid-19", and "global community" keywords from "PubMed", "Web o "Google Scholar", and "MedRxiv" databases.

RESULTS

Omicron have been evolved to spread faster than previous variants of concern, but it infects people lesser than other variants, Delta for example. Omicron can also escape vaccine-induced immunity more than previous SARS-CoV-2 variants.

DISCUSSION

Despite possible lower lethal risks than previous strains, Omicron may provide populations with a higher community transmission and a higher hospitalization load, which potentially overwhelm already exhausted health care systems. Therefore, we need to get used to the "New Normal" and maintain health recommendations to help decrease spreading of the virus and buy more time for the scientists to dive deeper into potential ways of tackling Covid-19, more than ever.

摘要

引言

2021年11月26日,世界卫生组织将一种新型严重急性呼吸综合征冠状病毒2(SARS-CoV-2)毒株指定为值得关注的变异株,并命名为奥密克戎。这一消息引发了全球范围的恐慌和焦虑浪潮,而许多人则像两年前一样,开始为节日季做准备。在其被指定近一个月后,六大洲的国家都从基因组序列中报告了奥密克戎毒株。这引发了国际社会对新冠疫情新时代的警报,尽管进行了大量疫苗接种,但世界各地仍报告了新病例和住院人数的激增。

方法

使用“SARS-CoV-2”“奥密克戎”“B.1.1.529”“新冠病毒病”和“全球社区”等关键词,从“PubMed”“科学网”“谷歌学术”和“MedRxiv”数据库中检索并获取了2021年11月26日至2022年3月21日发表的科学文献。

结果

奥密克戎毒株已进化到比之前值得关注的变异株传播速度更快,但它感染人的能力比其他变异株弱,例如德尔塔毒株。奥密克戎毒株也比之前的SARS-CoV-2变异株更能逃避疫苗诱导的免疫力。

讨论

尽管奥密克戎毒株的致死风险可能比之前的毒株低,但它可能使人群具有更高的社区传播率和更高的住院负担,这可能使本已不堪重负的医疗系统不堪承受。因此,我们需要适应“新常态”,并坚持健康建议,以帮助减少病毒传播,为科学家们争取更多时间,使其比以往任何时候都更深入地研究应对新冠病毒病的潜在方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec23/9017627/ce946dc21c1e/IID3-10-e618-g001.jpg

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