Zhang Fen, Niu Yanling, Li Yantao, Yao Qian, Chen Xiaoqi, Zhou Haijun, Zhou Mengmeng, Xiao Jijun
Institute of Energy Resources, Hebei Academy of Sciences 050081 Shijiazhuang Hebei Province China
School of Materials Science and Engineering, Hebei University of Science and Technology 050018 Shijiazhuang Hebei Province China
RSC Adv. 2021 Aug 31;11(46):29042-29051. doi: 10.1039/d1ra05555k. eCollection 2021 Aug 23.
Smart polymeric vesicles with both tertiary amine and epoxy functional groups were fabricated for the first time a reversible addition-fragmentation chain transfer dispersion polymerization approach, using (2-(diisopropylamino)ethyl methacrylate (DIPEMA) and glycidyl methacrylate (GlyMA) in an ethanol-water mixture. Monitoring of the polymerization revealed the low molecular weight distributions and the intermediate structures of spheres and worms, indicating an evolution in particle morphology. A phase diagram was constructed for reproducible fabrication of the vesicles, and copolymer composition was found to be more related to particle morphology. The vesicles exhibited superior structural stability for the cross-linking of the core through epoxydiamine chemistry, and intelligent pH responsibility due to the presence of the tertiary amine groups. The cross-linked vesicles showed good stability and reversibility during the swelling and shrinking cycles by switching the pH values, which endowed them with potential cell-like transmission functions. This research thus provides a method for producing structurally stable pH-responsive polymeric vesicles, and the reported vesicles are based on commercially available starting materials for possible industrial scale-up.
首次采用可逆加成-断裂链转移分散聚合法，以甲基丙烯酸-2-(二异丙基氨基)乙酯（DIPEMA）和甲基丙烯酸缩水甘油酯（GlyMA）为原料，在乙醇-水混合体系中制备了同时含有叔胺和环氧官能团的智能聚合物囊泡。对聚合过程的监测显示出低分子量分布以及球形和蠕虫状的中间结构，表明颗粒形态在演变。构建了相图以可重复地制备囊泡，并且发现共聚物组成与颗粒形态的关系更为密切。这些囊泡通过环氧二胺化学对核心进行交联表现出优异的结构稳定性，并且由于叔胺基团的存在而具有智能pH响应性。通过切换pH值，交联囊泡在溶胀和收缩循环过程中表现出良好的稳定性和可逆性，这赋予了它们潜在的类细胞传输功能。因此，本研究提供了一种制备结构稳定的pH响应性聚合物囊泡的方法，并且所报道的囊泡基于可商购的起始材料，有可能实现工业规模放大。
