Qu Qingwu, Liu Guangyao, Lv Xiaoqing, Zhang Baohua, An Zesheng
Institute of Nanochemistry and Nanobiology, College of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China.
ACS Macro Lett. 2016 Mar 15;5(3):316-320. doi: 10.1021/acsmacrolett.6b00066. Epub 2016 Feb 12.
In situ cross-linking of nano-objects with controllable morphologies in polymerization-induced self-assembly (PISA) has been a challenge because cross-linking lowers chain mobility and hence inhibits morphology transition. Herein, we propose a novel strategy that allows in situ cross-linking of vesicles in PISA in an aqueous dispersion polymerization formulation. This is realized by utilizing an asymmetric cross-linker bearing two vinyl groups of differing reactivities such that cross-linking is delayed to the late stage of polymerization when morphology transition has completed. Cross-linked vesicles with varying degrees (1-5 mol %) of cross-links were prepared, and their resistance to solvent dissolution and surfactant disruption was investigated. It was found that vesicles with ≥2 mol % cross-links were able to retain their structural integrity and colloidal stability when dispersed in DMF or in the presence of 1% of an anionic surfactant sodium dodecyl sulfate.
在聚合诱导自组装（PISA）过程中，对具有可控形态的纳米物体进行原位交联一直是一项挑战，因为交联会降低链的流动性，从而抑制形态转变。在此，我们提出了一种新颖的策略，该策略允许在水分散聚合配方中对PISA中的囊泡进行原位交联。这是通过使用带有两个反应活性不同的乙烯基的不对称交联剂来实现的，这样交联就会延迟到聚合后期形态转变完成时进行。制备了具有不同交联度（1-5摩尔%）的交联囊泡，并研究了它们对溶剂溶解和表面活性剂破坏的抗性。结果发现，当分散在N，N-二甲基甲酰胺（DMF）中或存在1%的阴离子表面活性剂十二烷基硫酸钠时，交联度≥2摩尔%的囊泡能够保持其结构完整性和胶体稳定性。
