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关于极性基团对直接纳米级疏水相互作用及两亲性肽组装的扰动效应的综述

A minireview on the perturbation effects of polar groups to direct nanoscale hydrophobic interaction and amphiphilic peptide assembly.

作者信息

Zhang Feiyi, Yu Lanlan, Zhang Wenbo, Liu Lei, Wang Chenxuan

机构信息

Institute for Advanced Materials, Jiangsu University Zhenjiang Jiangsu 212013 China

State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College Beijing 100005 China

出版信息

RSC Adv. 2021 Aug 25;11(46):28667-28673. doi: 10.1039/d1ra05463e. eCollection 2021 Aug 23.

DOI:10.1039/d1ra05463e
PMID:35478591
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9038178/
Abstract

Hydrophobic interaction provides the essential driving force for creating diverse native and artificial supramolecular architectures. Accumulating evidence leads to a hypothesis that the hydrophobicity of a nonpolar patch of a molecule is non-additive and susceptible to the chemical context of a judicious polar patch. However, the quantification of the hydrophobic interaction at the nanoscale remains a central challenge to validate the hypothesis. In this review, we aim to outline the recent efforts made to determine the hydrophobic interaction at a nanoscopic length scale. The advances achieved in the understanding of proximal polar groups perturbing the magnitude of hydrophobic interaction generated by the nonpolar patch are introduced. We will also discuss the influence of chemical heterogeneity on the modulation of amphiphilic peptide/protein assembly and molecular recognition.

摘要

疏水相互作用为构建多样的天然和人工超分子结构提供了关键驱动力。越来越多的证据支持这样一种假说：分子中非极性区域的疏水性并非简单的加和性，而是易受明智选择的极性区域化学环境的影响。然而，在纳米尺度上对疏水相互作用进行量化，仍然是验证该假说的核心挑战。在这篇综述中，我们旨在概述近期在纳米尺度上测定疏水相互作用所做的努力。介绍了在理解近端极性基团对非极性区域产生的疏水相互作用强度的扰动方面所取得的进展。我们还将讨论化学异质性对两亲性肽/蛋白质组装和分子识别调控的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c15/9038178/9ebbdf496cec/d1ra05463e-f7.jpg
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