Deva Krishnapriya, Rana Nivedita, Kumar Rajender, Mittal Bhagwant Rai
Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Indian J Nucl Med. 2022 Jan-Mar;37(1):23-28. doi: 10.4103/ijnm.ijnm_112_21. Epub 2022 Mar 25.
We aimed to evaluate the radiation exposure to patients undergoing positron emission tomography/computed tomography (PET/CT)-guided biopsies.
Patients undergoing PET/CT-guided biopsy were recruited prospectively from October 2019 to April 2020. PET/CT-guided biopsy from a tracer avid site was done using an automated-robotic-arm 1 h after intravenous injection of F-18-fluorodeoxyglucose (FDG) (2-5 mCi) or Ga-68-PSMA (1-4 mCi). Regional CT-images were acquired for biopsy planning and confirmation of needle placement. The internal radiation exposure due to the PET component was estimated using the value of activity injected and dose-coefficient for FDG and PSMA. The external radiation exposure due to the CT component was estimated using the value of dose length product and organ coefficients conversion factor. The total effective dose during the procedure was calculated by adding exposure due to both CT and PET components. Percentage contribution from CT and PET component to total effective dose was compared using a paired -test.
A total of 101 patients (76 males) were recruited for PET/CT-guided biopsy using FDG ( = 79) and PSMA ( = 22). The mean effective-dose due to PET and CT components and total effective-dose was 2.49 ± 1.02 mSv, 2.35 ± 1.03 mSv and 4.83 ± 1.90 mSv, respectively, for FDG-guided procedures and 1.60 ± 0.57 mSv, 3.06 ± 1.36 mSv, and 4.66 ± 1.37 mSv for Ga-68-PSMA-guided procedures. The percentage contribution of PET and CT in total effective-dose was comparable in F-18-FDG and Ga-68-PSMA PET/CT-guided biopsy procedures; however, for Ga-68-PSMA PET/CT-biopsies, CT contributed a higher radiation dose than PET component.
PET/CT-guided biopsy is a safe interventional procedure, and radiation exposure to the patients was less than routine whole-body PET/CT-imaging.
我们旨在评估接受正电子发射断层扫描/计算机断层扫描（PET/CT）引导下活检的患者所受到的辐射暴露。
2019年10月至2020年4月前瞻性招募接受PET/CT引导下活检的患者。在静脉注射F-18-氟脱氧葡萄糖（FDG）（2-5毫居里）或Ga-68-PSMA（1-4毫居里）1小时后，使用自动机械臂对示踪剂摄取部位进行PET/CT引导下活检。采集区域CT图像用于活检规划和确认针的放置位置。利用注入活度值以及FDG和PSMA的剂量系数估算PET部分所致的体内辐射暴露。利用剂量长度乘积值和器官系数转换因子估算CT部分所致的体外辐射暴露。通过将CT和PET两部分的暴露量相加计算出该过程中的总有效剂量。使用配对t检验比较CT和PET部分对总有效剂量的百分比贡献。
共招募101例患者（76例男性）接受使用FDG（n = 79）和PSMA（n = 22）的PET/CT引导下活检。对于FDG引导的操作，PET和CT部分以及总有效剂量的平均有效剂量分别为2.49±1.02毫希沃特、2.35±1.03毫希沃特和4.83±1.90毫希沃特；对于Ga-68-PSMA引导的操作，分别为1.60±0.57毫希沃特、3.06±1.36毫希沃特和4.66±1.37毫希沃特。在F-18-FDG和Ga-68-PSMA PET/CT引导下活检操作中，PET和CT在总有效剂量中的百分比贡献相当；然而，对于Ga-68-PSMA PET/CT活检，CT贡献的辐射剂量高于PET部分。
PET/CT引导下活检是一种安全的介入性操作，患者所受到的辐射暴露低于常规全身PET/CT成像。
