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头颈部鳞状细胞癌中肌球蛋白预后意义和免疫特征的综合全景

Comprehensive Landscape of Prognostic Significance and Immune Characteristics of Myosins in Squamous Cell Carcinoma of the Head and Neck.

机构信息

School of Clinical Medicine, Weifang Medical University, Weifang, China.

Department of Otolaryngology Head and Neck Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China.

出版信息

J Immunol Res. 2022 Apr 18;2022:5501476. doi: 10.1155/2022/5501476. eCollection 2022.

DOI:10.1155/2022/5501476
PMID:35478939
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9038433/
Abstract

Myosin superfamily, a large and diverse family of molecular motors important for cell motility and migration, has been illustrated to play contradictory roles during the development of several kinds of tumors. However, the function and prognostic values of MYOs in head and neck squamous cell carcinoma (HNSCC) still remain largely unknown. In the current manuscript, the expression levels and clinical data of MYOs in HNSCC were investigated by online databases, including Oncomine, GEPIA, GEO, TCGA, HPA, UALCAN, Kaplan-Meier plotter, and CancerSEA; we found that the expression levels of MYO1B, MYO5A, and MYO10 were significantly elevated in HNSCC tissues, which were also correlated with the unfavorable overall survival (OS) of the patients. Furthermore, MYO1B/MYO5A/MYO10 interacting genes were identified, and the protein-protein interaction (PPI) networks were constructed by STRING and GeneMANIA. The enrichment analysis revealed that MYO1B/MYO5A/MYO10 associated genes mainly participated in cell metastasis and EMT processes, which were also confirmed by cell functional experiments. At last, the ssGSEA method was conducted to investigate the extent of immune cell infiltration, and we found that both the expression of MYO1B/MYO5A/MYO10 were closely correlated with the infiltration of immune cells in HNSCC. These findings implied that MYO1B, MYO5A, and MYO10 as novel prognostic factors for HNSCC and provided new strategy for HNSCC treatment.

摘要

肌球蛋白超家族是一个庞大而多样化的分子马达家族，对细胞运动和迁移很重要，已有研究表明其在多种肿瘤的发生发展中发挥着矛盾的作用。然而，MYOs 在头颈部鳞状细胞癌（HNSCC）中的功能和预后价值仍知之甚少。在本研究中，通过在线数据库，包括 Oncomine、GEPIA、GEO、TCGA、HPA、UALCAN、Kaplan-Meier plotter 和 CancerSEA，研究了 HNSCC 中 MYOs 的表达水平和临床数据，发现 MYO1B、MYO5A 和 MYO10 在 HNSCC 组织中的表达水平显著升高，并且与患者的不良总生存（OS）相关。此外，还鉴定了 MYO1B/MYO5A/MYO10 相互作用的基因，并通过 STRING 和 GeneMANIA 构建了蛋白质-蛋白质相互作用（PPI）网络。富集分析表明，MYO1B/MYO5A/MYO10 相关基因主要参与细胞转移和 EMT 过程，这也通过细胞功能实验得到了证实。最后，通过 ssGSEA 方法研究了免疫细胞浸润的程度，发现 MYO1B/MYO5A/MYO10 的表达与 HNSCC 中免疫细胞的浸润密切相关。这些发现表明 MYO1B、MYO5A 和 MYO10 是 HNSCC 的新型预后因素，并为 HNSCC 的治疗提供了新的策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c6a/9038433/26dc72f0541a/JIR2022-5501476.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c6a/9038433/7fed5db526e5/JIR2022-5501476.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c6a/9038433/fbd6b540ed4e/JIR2022-5501476.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c6a/9038433/f921f97515f9/JIR2022-5501476.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c6a/9038433/4a07ddcd9a3d/JIR2022-5501476.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c6a/9038433/fe22d7988cd7/JIR2022-5501476.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c6a/9038433/551ca836e4ef/JIR2022-5501476.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c6a/9038433/cad5ff5cf57e/JIR2022-5501476.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c6a/9038433/53cd367c62c7/JIR2022-5501476.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c6a/9038433/26dc72f0541a/JIR2022-5501476.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c6a/9038433/7fed5db526e5/JIR2022-5501476.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c6a/9038433/fbd6b540ed4e/JIR2022-5501476.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c6a/9038433/f921f97515f9/JIR2022-5501476.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c6a/9038433/4a07ddcd9a3d/JIR2022-5501476.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c6a/9038433/fe22d7988cd7/JIR2022-5501476.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c6a/9038433/551ca836e4ef/JIR2022-5501476.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c6a/9038433/cad5ff5cf57e/JIR2022-5501476.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c6a/9038433/53cd367c62c7/JIR2022-5501476.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c6a/9038433/26dc72f0541a/JIR2022-5501476.009.jpg

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