Liu Ying, Zhou Lin, Xu Yunfei, Li Kexin, Zhao Yao, Qiao Haoduo, Xu Qing, Zhao Jie
Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, China.
Front Cell Dev Biol. 2022 Apr 11;10:864635. doi: 10.3389/fcell.2022.864635. eCollection 2022.
Ferroptosis is a new form of regulatory cell death named by Dixon in 2012, which is characterized by the accumulation of lipid peroxides and iron ions. Molecular chaperones are a class of evolutionarily conserved proteins in the cytoplasm. They recognize and bind incompletely folded or assembled proteins to help them fold, transport or prevent their aggregation, but they themselves do not participate in the formation of final products. As the largest number of molecular chaperones, heat shock proteins can be divided into five families: HSP110 (HSPH), HSP90 (HSPC), HSP70 (HSPA), HSP40 (DNAJ) and small heat shock proteins (HSPB). Different heat shock proteins play different roles in promoting or inhibiting ferroptosis in different diseases. It is known that ferroptosis is participated in tumors, nervous system diseases, renal injury and ischemia-reperfusion injury. However, there are few reviews about the relationship of heat shock proteins and ferroptosis. In this study, we systematically summarize the roles of heat shock proteins in the occurrence of ferroptosis, and predict the possible mechanisms of different families of heat shock proteins in the development of ferroptosis.
铁死亡是2012年由迪克森命名的一种新型调节性细胞死亡形式，其特征是脂质过氧化物和铁离子的积累。分子伴侣是细胞质中一类进化保守的蛋白质。它们识别并结合未完全折叠或组装的蛋白质，以帮助它们折叠、运输或防止其聚集，但它们本身不参与最终产物的形成。作为数量最多的分子伴侣，热休克蛋白可分为五个家族：HSP110（HSPH）、HSP90（HSPC）、HSP70（HSPA）、HSP40（DNAJ）和小热休克蛋白（HSPB）。不同的热休克蛋白在不同疾病中促进或抑制铁死亡方面发挥着不同作用。已知铁死亡参与肿瘤、神经系统疾病、肾损伤和缺血再灌注损伤。然而，关于热休克蛋白与铁死亡关系的综述较少。在本研究中，我们系统总结了热休克蛋白在铁死亡发生中的作用，并预测了不同家族热休克蛋白在铁死亡发展中的可能机制。
