Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, China.
College of Animal Sciences, Jilin University, Changchun, China.
Front Endocrinol (Lausanne). 2024 Aug 2;15:1390013. doi: 10.3389/fendo.2024.1390013. eCollection 2024.
Polycystic ovarian syndrome (PCOS) is a common heterogeneous reproductive endocrine metabolic disorder in women of reproductive age characterized by clinical and biochemical hyperandrogenemia, ovulation disorders, and polycystic ovarian morphology. Ferroptosis is a novel type of cell death driven by iron accumulation and lipid peroxidation. Ferroptosis plays a role in maintaining redox balance, iron metabolism, lipid metabolism, amino acid metabolism, mitochondrial activity, and many other signaling pathways linked to diseases. Iron overload is closely related to insulin resistance, decreased glucose tolerance, and the occurrence of diabetes mellitus. There is limited research on the role of ferroptosis in PCOS. Patients with PCOS have elevated levels of ferritin and increased reactive oxygen species in ovarian GCs. Studying ferroptosis in PCOS patients is highly important for achieving personalized treatment. This article reviews the progress of research on ferroptosis in PCOS, introduces the potential connections between iron metabolism abnormalities and oxidative stress-mediated PCOS, and provides a theoretical basis for diagnosing and treating PCOS.
多囊卵巢综合征（PCOS）是一种常见的异质性生殖内分泌代谢紊乱，发生于育龄妇女，其特征为临床和生化高雄激素血症、排卵障碍和多囊卵巢形态。铁死亡是一种新型的由铁蓄积和脂质过氧化驱动的细胞死亡形式。铁死亡在维持氧化还原平衡、铁代谢、脂质代谢、氨基酸代谢、线粒体活性以及与疾病相关的许多其他信号通路中发挥作用。铁过载与胰岛素抵抗、葡萄糖耐量降低和糖尿病的发生密切相关。铁死亡在 PCOS 中的作用研究有限。PCOS 患者的铁蛋白水平升高，卵巢颗粒细胞中的活性氧增加。研究 PCOS 患者的铁死亡对于实现个体化治疗非常重要。本文综述了铁死亡在 PCOS 中的研究进展，介绍了铁代谢异常与氧化应激介导的 PCOS 之间的潜在联系，并为 PCOS 的诊断和治疗提供了理论依据。
