Wang Liqun, Yan Ning, Guo Rongrong, Pu Lining, Dang Yuqi, Pan Ruiping, Niu Yang
Department of Epidemiology and Statistics, School of Public Health and Management at Ningxia Medical University, Yinchuan, 750004, People's Republic of China.
Heart Centre & Department of Cardiovascular Diseases, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, People's Republic of China.
Patient Prefer Adherence. 2022 Apr 21;16:1085-1092. doi: 10.2147/PPA.S354181. eCollection 2022.
Few studies have explored the association between neighborhood social cohesion (NSC), a type of social capital, and the quality of life of patients with type 2 diabetes mellitus (T2DM). In addition, the potential mechanism for this association remains unclear. The current study examined the mediation effect of depressive symptoms on the relationship between NSC and quality of life among diabetes patients in China.
A cross-sectional study of 1747 T2DM patients was conducted. The specific quality of life (DSQL), Center for Epidemiological Survey Depression (CES-D), and social capital scales were administered using a face-to-face survey. Partial correlation analysis and a linear regression model were employed to explore the relationship between NSC, depressive symptoms, and quality of life. Bootstrap analysis using PROCESS was used to test the mediation model.
After controlling for covariates, NSC was negatively correlated with depressive symptoms (r=-0.24, P<0.01) and DSQL score (r=-0.20, P<0.01) while depressive symptoms were positively correlated with DSQL score (r=0.46, P<0.01). Linear regression analysis also found that NSC was negatively associated with the DSQL score, while depressive symptoms were positively associated with the DSQL score. Depressive symptoms mediated the relationship between NSC and quality of life in T2DM patients (explaining 50.7% of the total variance).
NSC was positively associated with improved quality of life among Chinese T2DM patients in this study, and depressive symptoms were likely to partially explain this relationship. These findings may be used to help maintain a good quality of life among at-risk individuals. Additional prospective studies are needed to confirm these findings.
很少有研究探讨邻里社会凝聚力（NSC）这种社会资本类型与2型糖尿病（T2DM）患者生活质量之间的关联。此外，这种关联的潜在机制仍不清楚。本研究考察了抑郁症状在中国糖尿病患者中NSC与生活质量关系中的中介作用。
对1747例T2DM患者进行了横断面研究。通过面对面调查使用特定生活质量量表（DSQL）、流行病学调查中心抑郁量表（CES-D）和社会资本量表。采用偏相关分析和线性回归模型探讨NSC、抑郁症状与生活质量之间的关系。使用PROCESS进行的Bootstrap分析用于检验中介模型。
在控制协变量后，NSC与抑郁症状（r = -0.24，P < 0.01）和DSQL评分（r = -0.20，P < 0.01）呈负相关，而抑郁症状与DSQL评分呈正相关（r = 0.46，P < 0.01）。线性回归分析还发现NSC与DSQL评分呈负相关，而抑郁症状与DSQL评分呈正相关。抑郁症状介导了T2DM患者中NSC与生活质量的关系（解释了总方差的50.7%）。
本研究中，NSC与中国T2DM患者生活质量的改善呈正相关，抑郁症状可能部分解释了这种关系。这些发现可能有助于维持高危个体的良好生活质量。需要更多的前瞻性研究来证实这些发现。
