Institute of Endocrinology, Laboratory of Diabetology, Almazov National Medical Research Center, Saint Petersburg, Russia.
Faculty of Clinical Psychology, State Pediatric Medical University, Saint Petersburg, Russia.
J Comp Eff Res. 2019 Jan;8(2):113-120. doi: 10.2217/cer-2018-0105. Epub 2018 Dec 14.
To identify correlations between quality of life (QoL), emotional and mental state in patients with Type 2 diabetes mellitus (T2DM) and to evaluate its contribution in prediction of compliance.
MATERIALS & METHODS: The T2DM patients aged 18-75 years with at least 12 weeks of stable hypoglycemic therapy were included to this cross-sectional study. We used Mini Mental State Examination (MMSE) for mental state assessment, Hospital Anxiety and Depression Scale (HADS) for anxiety and depression level and EQ-5D for QoL. Compliance level was self-reported by patients.
The QoL positively correlates with MMSE score (p < 0.0001) and negatively with HADS anxiety (p < 0.0001) and depression (p < 0.0001) levels. The MMSE score is higher (p < 0.0001), and both HADS levels are lower (p < 0.01) in patients with higher compliance level.
Cognitive function and psychoemotional state in T2DM patients are important for treatment compliance and QoL and are to be corrected whenever possible.
确定 2 型糖尿病（T2DM）患者的生活质量（QoL）、情绪和精神状态之间的相关性，并评估其对依从性预测的贡献。
本横断面研究纳入了年龄在 18-75 岁之间、至少接受 12 周稳定降糖治疗的 T2DM 患者。我们使用简易精神状态检查（MMSE）评估精神状态，使用医院焦虑和抑郁量表（HADS）评估焦虑和抑郁水平，使用 EQ-5D 评估 QoL。患者自我报告依从性水平。
QoL 与 MMSE 评分呈正相关（p<0.0001），与 HADS 焦虑（p<0.0001）和抑郁（p<0.0001）评分呈负相关。依从性水平较高的患者 MMSE 评分较高（p<0.0001），HADS 评分较低（p<0.01）。
T2DM 患者的认知功能和心理情绪状态对治疗依从性和 QoL 很重要，应尽可能予以纠正。
