Na Zhijing, Jiang Hongyu, Meng Yaxin, Song Jiahui, Feng Di, Fang Yuanyuan, Shi Bei, Li Da
Center of Reproductive Medicine, Shengjing Hospital of China Medical University, No.36, SanHao Street, Shenyang 110004, China.
Education Center for Clinical Skill Practice, China Medical University, Shenyang 110122, China.
EClinicalMedicine. 2022 Apr 16;47:101379. doi: 10.1016/j.eclinm.2022.101379. eCollection 2022 May.
Polycystic ovary syndrome (PCOS) is closely linked to metabolic disorders. Recent reports have identified galactose as having strong associations with metabolic disorders, however, the correlation between galactose and PCOS remains largely unknown.
The serum galactose levels of 104 patients with PCOS and 98 controls were measured, and their relationships with several metabolic parameters were analyzed. The study took place at the Center for Reproductive Medicine at Shengjing Hospital of China Medical University, Shenyang, China from July 13 to Oct 20, 2020. The relationships between serum galactose and PCOS as well as PCOS-related insulin resistance were investigated via logistic regression analyses, and the performance of serum galactose as a potential biomarker for PCOS was evaluated using receiver operating characteristic curve analysis.
Higher serum galactose levels were observed in the patients with PCOS than in the controls ( = 0.001). There was still a correlation between circulating galactose levels and PCOS after adjusting for covariates ( = 0.002; odds ratio (OR), 1.133; 95% confidence interval (CI) 1.047-1.227). Serum galactose levels were shown to be most closely related to the fasting serum insulin level ( = 0.370, = 0.001) and were higher in the insulin-resistant subgroup than in the non-insulin-resistant subgroup of patients with PCOS ( = 0.001). There was no difference in serum galactose levels between the insulin-resistant and non-insulin-resistant subgroups of women in the control group ( > 0.05). Furthermore, higher serum galactose levels were shown to be associated with insulin resistance in PCOS ( = 0.004; OR, 26.017; 95% CI, 2.907-232.810). The area under the curve for galactose-mediated prediction of PCOS was 80.0%, with a sensitivity of 71.0% and a specificity of 86.4%.
Higher circulating galactose levels correlate with PCOS and PCOS-related insulin resistance; therefore, it may serve as a potential biomarker for patients with PCOS. These findings require further validation in a study with a larger sample size.
National Natural Science Foundation of China (No. 82,071,607 and 32,100,691); LiaoNing Revitalization Talents Program (No. XLYC1907071); Fok Ying Tung Education Foundation (No. 151,039); Key Research and Development Program of Liaoning Province (NO. 2,018,225,062); Outstanding Scientific Fund of Shengjing Hospital (No. 202,003).
多囊卵巢综合征（PCOS）与代谢紊乱密切相关。最近的报告已确定半乳糖与代谢紊乱有很强的关联，然而，半乳糖与PCOS之间的相关性在很大程度上仍不清楚。
测量了104例PCOS患者和98例对照者的血清半乳糖水平，并分析了它们与几个代谢参数的关系。该研究于2020年7月13日至10月20日在中国沈阳中国医科大学盛京医院生殖医学中心进行。通过逻辑回归分析研究血清半乳糖与PCOS以及PCOS相关胰岛素抵抗之间的关系，并使用受试者工作特征曲线分析评估血清半乳糖作为PCOS潜在生物标志物的性能。
PCOS患者的血清半乳糖水平高于对照组（P = 0.001）。在调整协变量后，循环半乳糖水平与PCOS之间仍存在相关性（P = 0.002；优势比（OR），1.133；95%置信区间（CI）1.047 - 1.227）。血清半乳糖水平显示与空腹血清胰岛素水平最密切相关（r = 0.370，P = 0.001），并且在PCOS患者的胰岛素抵抗亚组中高于非胰岛素抵抗亚组（P = 0.001）。对照组女性的胰岛素抵抗和非胰岛素抵抗亚组之间的血清半乳糖水平没有差异（P>0.05）。此外，较高的血清半乳糖水平显示与PCOS中的胰岛素抵抗相关（P = 0.004；OR，26.017；95% CI，2.907 - 232.810）。半乳糖介导的PCOS预测曲线下面积为80.0%，敏感性为71.0%，特异性为86.4%。
较高的循环半乳糖水平与PCOS和PCOS相关的胰岛素抵抗相关；因此，它可能作为PCOS患者的潜在生物标志物。这些发现需要在更大样本量的研究中进一步验证。
中国国家自然科学基金（编号82071607和32100691）；辽宁省振兴人才计划（编号XLYC1907071）；霍英东教育基金会（编号151039）；辽宁省重点研发计划（编号2018225062）；盛京医院杰出科学基金（编号202003）。
