Laboratory of Biophysics of Cell Membrane under Critical State, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V.A. Negovsky Research Institute of General Reanimatology, Moscow 107031, Russia.
Department of Medical and Biological Physics, Sechenov First Moscow State Medical University (Sechenov University), Moscow 119991, Russia.
Biomed Res Int. 2022 Apr 18;2022:1140176. doi: 10.1155/2022/1140176. eCollection 2022.
The ability of neutrophils and red blood cells (RBCs) to undergo significant deformations is a key to their normal functioning. Disruptions of these processes can lead to pathologies. This work studied the influence of structural configuration rearrangements of membranes after exposure to external factors on the ability of native membranes of neutrophils and RBCs to undergo deep deformation. The rearrangement of the structural configuration of neutrophil and RBC membranes under the influence of cytological fixatives caused nonlinear deformation phenomena. There were an increase in Young's modulus, a decrease in the depth of homogeneous bending, and a change in the distance between cytoskeletal junctions. Based on the results of the analysis of experimental data, a mathematical model was proposed that describes the process of deep bending of RBСs and neutrophil membranes.
中性粒细胞和红细胞（RBC）能够发生显著变形的能力是其正常功能的关键。这些过程的中断可能导致病理。这项工作研究了暴露于外部因素后细胞膜结构构象重排对原生中性粒细胞和 RBC 膜发生深层变形能力的影响。细胞固定剂的影响导致中性粒细胞和 RBC 细胞膜的结构构象重排产生非线性变形现象。杨氏模量增加，均匀弯曲深度减小，细胞骨架连接点之间的距离发生变化。基于对实验数据的分析结果，提出了一个数学模型，该模型描述了 RBC 和中性粒细胞膜的深层弯曲过程。
