Prahoveanu E, Boieru V, Petrescu A
Virologie. 1986 Oct-Dec;37(4):269-77.
The A 2/Romania 1/73 (H3N2) strain of influenza virus at the 15th passage on chick embryos was compared to the mouse adapted A0/PR8/34 (H0N1) strain, as regards pathogenicity for X-ray irradiated mice. Irradiated mice showed a greater sensitivity to influenza infection than nonirradiated controls, irrespective of the strain used: hemagglutinating (HA) titers were constantly higher in the first group of animals. Administration of a polypeptidic thymus extract to irradiated mice inoculated with the A0/PR8 strain had a protective effect and was followed by a decrease in mean HA titer from 1/3077 to 1/164. The authors discuss the possible mechanisms of the viral multiplication rate increase in irradiated animals and of the higher resistance against influenza infection noted in thymus-extract treated animals.
就对经X射线照射的小鼠的致病性而言，将流感病毒鸡胚传代15次的A 2/罗马尼亚1/73（H3N2）毒株与适应小鼠的A0/PR8/34（H0N1）毒株进行了比较。无论使用何种毒株，经照射的小鼠对流感感染的敏感性均高于未照射的对照：第一组动物的血凝（HA）滴度始终较高。给接种A0/PR8毒株的经照射小鼠施用一种多肽胸腺提取物具有保护作用，随后平均HA滴度从1/3077降至1/164。作者讨论了照射动物中病毒增殖率增加以及胸腺提取物处理动物中对流感感染抵抗力增强的可能机制。
