Joulaei Hassan, Keshani Parisa, Foroozanfar Zohre, Zamanian Daniel, Hassani Amirhossein, Parvizi Fateme, Khadem Yasaman, Omidifar Navid, Davarpanah Mohammad Ali
Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
HIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
Open Med (Wars). 2022 Apr 7;17(1):702-711. doi: 10.1515/med-2022-0469. eCollection 2022.
This study aimed to assess the association between serum zinc level with some inflammatory and immunity factors and the duration of hospitalization and mortality rate in patients diagnosed with Covid-19. In this cross-sectional study, blood samples were taken from polymerase chain reaction (PCR) positive patients. New patients diagnosed with Covid-19, admitted to different public hospital wards, were considered eligible for entering the study. The study was done on 179 hospitalized patients diagnosed with Covid-19. Fourteen patients died during the hospitalization and the in-hospital mortality rate was 7.8%, with 9.1% (13 patients) of patients with serum zinc level less than 70 mcg/dL and 3.4% (1 patient) of patients with zinc levels more than 70 mcg/dL. Higher levels of zinc were significantly associated with a higher and lower level of interferon-gamma (IFN-γ) (-value = 0.035) and interleukin (IL)-6 (-value = 0.004), respectively. The level of serum zinc did not have a significant association with mortality even after adjusting for confounding factors. The relationship between zinc level and the duration of hospitalization was also not significant. In conclusion, serum zinc level had an association with IL-6 and IFN-γ level, but it did not have any significant association with hospital duration or mortality.
本研究旨在评估血清锌水平与一些炎症和免疫因子之间的关联，以及新冠病毒病（Covid-19）确诊患者的住院时间和死亡率。在这项横断面研究中，从聚合酶链反应（PCR）呈阳性的患者采集血样。确诊为Covid-19且入住不同公立医院病房的新患者被认为符合纳入本研究的条件。该研究对179例确诊为Covid-19的住院患者进行。14例患者在住院期间死亡，住院死亡率为7.8%，血清锌水平低于70微克/分升的患者中有9.1%（13例）死亡，锌水平高于70微克/分升的患者中有3.4%（1例）死亡。较高的锌水平分别与较高和较低水平的干扰素-γ（IFN-γ）（P值 = 0.035）和白细胞介素（IL）-6（P值 = 0.004）显著相关。即使在对混杂因素进行校正后，血清锌水平与死亡率也没有显著关联。锌水平与住院时间之间的关系也不显著。总之，血清锌水平与IL-6和IFN-γ水平有关，但与住院时间或死亡率没有任何显著关联。
