埃及新冠肺炎患者血清锌水平与临床结局的关联
Association of serum zinc level and clinical outcome in Egyptian COVID-19 patients.
作者信息
Mansour Ahmed M F, El Nakeeb Noha, Kamal Norhan Khaled Mohamed, ElGhandour Ahmed Mohamed
机构信息
Department of Internal Medicine, Hepatology and Gastroenterology, Ain Shams University, Cairo, Egypt.
出版信息
Egypt J Intern Med. 2022;34(1):72. doi: 10.1186/s43162-022-00159-z. Epub 2022 Sep 24.
BACKGROUND
Zinc is an anti-inflammatory and antioxidant micronutrient found in food. Due to its well-established role in immunity, it is currently being used in some clinical trials against coronavirus disease-2019 (COVID-19). This study aimed to assess the association between the mean serum zinc level in COVID-19 Egyptian patients and its relationship with disease severity. This cross-sectional study was conducted on sixty patients with confirmed COVID-19 infection. These patients were divided into two groups according to clinical outcome, group 1 which included 30 intensive care unit (ICU) patients and group 2 which included 30 patients who were admitted to the ward. Mean serum levels of zinc were compared between the two groups.
RESULTS
There was a statistically significant difference noted among study groups regarding the serum zinc level ( < 0.039), where lower mean serum zinc levels were noted in ICU patients compared to ward patients (70.6 ± 5.7 vs 73.8 ± 6.1).
CONCLUSION
Low serum zinc level is associated with the severe outcome of COVID-19 infection.
背景
锌是一种存在于食物中的具有抗炎和抗氧化作用的微量营养素。由于其在免疫方面已确立的作用，目前正在一些针对2019冠状病毒病（COVID-19）的临床试验中使用。本研究旨在评估埃及COVID-19患者的平均血清锌水平与其与疾病严重程度之间的关系。本横断面研究对60例确诊为COVID-19感染的患者进行。根据临床结果将这些患者分为两组，第1组包括30例重症监护病房（ICU）患者，第2组包括30例病房收治患者。比较两组之间的血清锌平均水平。
结果
研究组之间血清锌水平存在统计学显著差异（<0.039），与病房患者相比，ICU患者的血清锌平均水平较低（70.6±5.7 vs 73.8±6.1）。
结论
低血清锌水平与COVID-19感染的严重结局相关。
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