Kong Chenchen, Luo Yunjing, Zhang Wei, Lin Taifeng, Na Zhen, Liu Xuemei, Xie Ziqi
Beijing Key Laboratory of Environmental and Viral Oncology, Faculty of Environment and Life, Beijing University of Technology No. 100, Pingleyuan, Chaoyang District Beijing 100124 China
RSC Adv. 2022 Apr 20;12(19):12060-12067. doi: 10.1039/d2ra00131d. eCollection 2022 Apr 13.
Gold nanoclusters have good biocompatibility and can be easily modified to improve their luminescence properties. In this study, we prepared a new type of dual-emitting gold nanoclusters (d-Au NCs) for discriminative detection of phenylalanine and Fe with high selectivity and sensitivity. The fluorescence sensor which was synthesized without any further assembly or conjugation shows dual-emissions at 430 nm and 600 nm under a single excitation at 350 nm. Phenylalanine can turn on the red emission of the probe, while Fe can turn on its yellow emission and turn off the red emission. By detecting a variety of amino acids and metal ions, d-Au NCs showed good selectivity to phenylalanine and Fe. Finally, this method was applied to determine phenylalanine and Fe in lake water, human urine and milk, which has certain application prospects in the field of biology and environment.
金纳米簇具有良好的生物相容性，并且可以很容易地进行修饰以改善其发光性能。在本研究中，我们制备了一种新型的双发射金纳米簇（d-Au NCs），用于高选择性和高灵敏度地鉴别检测苯丙氨酸和铁。该荧光传感器无需任何进一步组装或共轭即可合成，在350nm的单一激发下，在430nm和600nm处呈现双发射。苯丙氨酸可开启探针的红色发射，而铁可开启其黄色发射并关闭红色发射。通过检测多种氨基酸和金属离子，d-Au NCs对苯丙氨酸和铁表现出良好的选择性。最后，该方法被应用于测定湖水、人尿和牛奶中的苯丙氨酸和铁，在生物和环境领域具有一定的应用前景。
