Department of Hepatitis & AIDS, Pasteur Institute of Iran, 1316943551, Tehran, Iran.
Immunotherapy. 2022 Jun;14(8):639-654. doi: 10.2217/imt-2022-0036. Epub 2022 Apr 28.
Whole tumor cell-based vaccines include all potential antigen-rich cell lysates to target a specific type of tumor without the need to find the best antigen candidate in protein- or peptide-based vaccines. Preparation of whole tumor cell lysates inducing cell death and inactivating immunosuppressive cytokine secretion from the tumor cells is highly enviable. Generally, modified whole tumor cells, tumor cell-derived exosomes, autologous tumor cell-derived ribonucleic acid, and personalized mutanome-derived tumor antigen are promising immunotherapeutic approaches. Autologous dendritic cells loaded with tumor-associated antigens also induce the generation of immunological memory and antitumor response as an effective method for the treatment of cancer. The present review briefly describes tumor cell-based vaccines as a promising strategy for eradication of cancer cells.
基于整个肿瘤细胞的疫苗包括所有潜在的富含抗原的细胞裂解物，旨在针对特定类型的肿瘤，而无需在基于蛋白质或肽的疫苗中寻找最佳抗原候选物。制备诱导肿瘤细胞死亡和使肿瘤细胞分泌的免疫抑制细胞因子失活的整个肿瘤细胞裂解物是非常可取的。一般来说，修饰后的整个肿瘤细胞、肿瘤细胞衍生的外泌体、自体肿瘤细胞衍生的核糖核酸和个性化突变体衍生的肿瘤抗原是很有前途的免疫治疗方法。负载肿瘤相关抗原的自体树突状细胞也可诱导产生免疫记忆和抗肿瘤反应，是治疗癌症的有效方法。本文简要描述了基于肿瘤细胞的疫苗作为消除癌细胞的一种有前途的策略。
