Department of Veterinary Medicine & Surgery, University of Missouri, Columbia, MO, USA.
J Feline Med Surg. 2022 Jun;24(6):e76-e84. doi: 10.1177/1098612X221090713. Epub 2022 Apr 28.
The study aimed to evaluate the safety and effectiveness of vitamin D supplementation with dietary 25-hydroxyvitamin D (25[OH]D) in adult cats.
Three levels of dietary 25(OH)D concentrations (4.9, 8.4, 11.8 µg/kg as fed) were received by five adult cats for 9 weeks, each in a randomized complete block design. Effects were determined on plasma or serum concentrations of 25(OH)D, 24,25-dihydroxyvitamin D, calcitriol, parathyroid hormone, ionized calcium, urinary excretions of phosphorus, calcium and magnesium, and clinical hematology and chemistry panels.
The lowest concentration of dietary 25(OH)D supported elevation of vitamin D status, with no adverse effects. Supplementation of 8.4 µg/kg 25(OH)D had significant effects on the urinary magnesium: creatinine ratio. Increasing supplementation up to 11.8 µg/kg 25(OH)D had significant effects on plasma concentrations of calcium and magnesium, and vitamin D metabolites.
Dietary supplementation with approximately 5.0 µg/kg of 25(OH)D or the ingested equivalence of 0.09 µg of 25(OH)D per metabolic body weight (kg) is a safe, potent and effective means for raising vitamin D status in cats. A higher dose with approximately 11.8 µg/kg of 25(OH)D resulted in elevation in C-3 epimers of 25(OH)D and slight elevation in plasma magnesium and calcium concentrations above their respective reference intervals.
本研究旨在评估成年猫通过饮食补充 25-羟维生素 D（25[OH]D）的安全性和有效性。
5 只成年猫接受了 3 种不同水平的饮食 25（OH）D 浓度（4.9、8.4、11.8μg/kg 干物质），采用随机完全区组设计，为期 9 周。通过检测 25（OH）D、24,25-二羟维生素 D、骨化三醇、甲状旁腺激素、离子钙、尿磷、钙和镁排泄量以及临床血液学和化学指标来评估效果。
最低浓度的饮食 25（OH）D 支持维生素 D 状态的升高，且无不良反应。补充 8.4μg/kg 25（OH）D 对尿镁：肌酐比值有显著影响。增加补充量至 11.8μg/kg 25（OH）D 对血浆钙和镁浓度以及维生素 D 代谢物有显著影响。
饮食补充约 5.0μg/kg 的 25（OH）D 或每代谢体重（kg）摄入 0.09μg 的 25（OH）D 等价物是提高猫维生素 D 状态的安全、有效和有力的方法。较高剂量的约 11.8μg/kg 25（OH）D 导致 25（OH）D 的 C-3 差向异构体升高，并使血浆镁和钙浓度轻微升高至各自的参考区间之上。
