Graduate School, Beijing University of Chinese Medicine, Beijing, China.
Department of Oncology, Dongfang Hospital Beijing University of Chinese Medicine, Beijing, China.
Bioengineered. 2022 Apr;13(4):11258-11268. doi: 10.1080/21655979.2022.2065742.
Thermal ablation is widely used in the treatment of lung cancer and is beneficial for the overall survival of patients in clinic. However, there is barely a priority in which ablation system should be chosen under different periods of tumor progression in lung cancer. The present study investigated different modes of thermal ablation systems in mice with transplanted Lewis lung carcinoma tumors and their various biological effects in local regions using untargeted metabolomics. The results showed that thermal ablation could significantly suppress tumor growth and the differentially expressed metabolites of tumors after ablation relative to untreated tumors concentrated on organic compounds, organic acids and derivatives, nucleosides, nucleotides, and lipids. The upregulated metabolites indicated an inflammatory reaction in the ablation groups at an early stage after ablation. Steroid hormone and tryptophan metabolism, which are associated with immune responses, were modulated after both cryoablation and hyperthermal ablation. Characteristically, the results also indicated that cryoablation suppressed glucose oxidation and carbohydrate metabolism of tumor, while hyperthermal ablation suppressed lipid metabolism of tumor. In conclusion, thermal ablation could inhibit tumor growth under either freezing or heating modes with characteristic different biological effects on tumors.
热消融被广泛应用于肺癌的治疗，有利于改善患者的总体生存。然而，在肺癌肿瘤进展的不同时期，几乎没有优先选择哪种消融系统的标准。本研究采用非靶向代谢组学方法，研究了移植 Lewis 肺癌小鼠模型中不同热消融系统的模式及其在局部区域的各种生物学效应。结果表明，与未治疗的肿瘤相比，热消融可显著抑制肿瘤生长和消融后肿瘤的差异表达代谢物，这些代谢物集中在有机化合物、有机酸及其衍生物、核苷、核苷酸和脂质上。消融组中上调的代谢物表明在消融后早期存在炎症反应。与免疫反应相关的类固醇激素和色氨酸代谢在冷冻和高热消融后都被调节。特征性地，结果还表明，冷冻消融抑制了肿瘤的葡萄糖氧化和碳水化合物代谢，而高热消融抑制了肿瘤的脂质代谢。总之，冷冻或加热模式的热消融均可抑制肿瘤生长，并对肿瘤产生特征性的不同生物学效应。
