无金属 - 5-巯基四唑和 2-巯基吡啶与不对称二芳基碘鎓盐的芳基化反应。
Metal-free -arylation of 5-mercaptotetrazoles and 2-mercaptopyridine with unsymmetrical diaryliodonium salts.
机构信息
Department of Chemical Sciences, Tezpur University, Napaam-784028, Assam, India.
Department of Chemistry, Indian Institute of Technology Guwahati, North Guwahati-781039, India.
出版信息
Org Biomol Chem. 2022 May 18;20(19):3890-3896. doi: 10.1039/d2ob00406b.
Herein, we demonstrate the application of unsymmetrical iodonium salts towards -arylation of heterocyclic thiols (especially tetrazole-5-thiols and pyridine-2-thiol) under metal-free conditions, affording a diverse range of di(hetero)aryl thioethers in moderate to good yields. A detailed study on the effects of counter-anions and the auxiliary of iodonium salts was conducted. Suitable auxiliary selection of the unsymmetrical iodonium salt offers flexibility for a wide range of aryl moieties and its incorporation into -arylation. The DFT study supports the experimental observations of chemoselective arylation.
在此，我们展示了不对称碘𬭩盐在无金属条件下用于杂环硫醇（特别是四唑-5-硫醇和吡啶-2-硫醇）的 -芳基化反应，以中等至良好的收率得到了各种不同的二（杂）芳基硫醚。我们详细研究了抗衡阴离子和碘𬭩盐助剂的影响。不对称碘𬭩盐的合适助剂选择为广泛的芳基部分及其 -芳基化提供了灵活性。DFT 研究支持了化学选择性芳基化的实验观察。
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