胃癌的环境和遗传风险因素。
Environmental and genetic risk factors for gastric cancer.
机构信息
Department of Surgery, Surgical Outcome and Quality Improvement Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
出版信息
J Surg Oncol. 2022 Jun;125(7):1096-1103. doi: 10.1002/jso.26869.
Gastric cancer is a heterogeneous and prevalent disease. The traditional environmental exposures associated with an elevated risk of gastric cancer are less prevalent in the United States today. Genetic risks and risks associated with inflammation remain. Most cases are sporadic and familial clustering is observed in about 10% of the cases. Hereditary gastric cancer accounts for a very low percentage of cases. Here we review the genetic and environmental risk factors associated with the disease.
胃癌是一种异质性和普遍存在的疾病。与胃癌风险升高相关的传统环境暴露在美国现今已不那么普遍。但仍存在遗传风险和与炎症相关的风险。大多数病例为散发性，约 10%的病例观察到家族聚集性。遗传性胃癌占极少数病例。本文综述了与该疾病相关的遗传和环境危险因素。
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