Henmi A, Sato H, Wataya T, Inaniwa Y, Mori Y
Acta Pathol Jpn. 1986 Dec;36(12):1911-9. doi: 10.1111/j.1440-1827.1986.tb02256.x.
A case of neurothekeoma in a 52-year-old woman is reported. The tumor developed on the medial aspect of the right nostril as a well-demarcated, dome-shaped, erythematous nodule of rubbery consistency. Microscopically, it consisted of numerous nests and cords of spindle-shaped cells in the dermis. Some of the tumor cell nests appeared epithelial-like, while the other areas showed a myxomatous appearence with various amount of mucinous matrix in the intercellular space. Neurothekeoma is a benign cutaneous tumor, and is considered to be of schwann cell origin. In the present case, the tumor cells did not stain positively for S-100 protein, despite the light microscopic suggestion of peripheral nerve origin. Ultrastructurally, most tumor cells contained a large number of myelinoid figures. This ultrastructural finding appears to be a useful diagnostic characteristics of neurothekeomas.
报告了一例52岁女性的神经鞘黏液瘤。肿瘤发生于右鼻孔内侧，为边界清晰、圆顶状、质地似橡胶的红色结节。显微镜下，肿瘤由真皮内大量梭形细胞巢和条索组成。部分肿瘤细胞巢呈上皮样，而其他区域呈黏液瘤样外观，细胞间隙有不同量的黏液基质。神经鞘黏液瘤是一种良性皮肤肿瘤，被认为起源于施万细胞。在本病例中，尽管光镜提示肿瘤起源于周围神经，但肿瘤细胞S-100蛋白染色未呈阳性。超微结构上，大多数肿瘤细胞含有大量髓鞘样结构。这一超微结构发现似乎是神经鞘黏液瘤的一个有用诊断特征。
