Monroy A
Adv Exp Med Biol. 1986;207:25-35. doi: 10.1007/978-1-4613-2255-9_3.
In 1902, Boveri introduced the important concept that for the success of fertilization the gametes must activate one another. Based primarily on studies on the sea urchin and ascidian fertilization the suggestion is presented here that "activation" of the spermatozoon actually involves a switching off of its metabolic machinery as a result of its interaction with the sperm receptors of the egg envelopes and prior to its fusion with the egg. Concerning the activation of the egg, there is a fairly large body of old and new experimental evidence that activation per se does not require sperm incorporation. Indeed, the chain of reactions culminating in the activation of the egg is initiated upon attachment of the spermatozoon to the egg plasma membrane.
1902年，博韦里提出了一个重要概念，即受精成功的前提是配子必须相互激活。本文主要基于对海胆和海鞘受精的研究，提出如下观点：精子的“激活”实际上是其与卵膜上的精子受体相互作用后、与卵子融合之前，其代谢机制关闭的结果。关于卵子的激活，有大量新旧实验证据表明，激活本身并不需要精子进入。事实上，精子附着在卵质膜上时，就启动了最终导致卵子激活的一系列反应。
