代谢组学研究表明，酚酰胺是导致蜂花粉具有抑制酪氨酸酶活性的主要化学成分。
Metabolomics reveals that phenolamides are the main chemical components contributing to the anti-tyrosinase activity of bee pollen.
机构信息
College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China; Wuhan Engineering Research Center of Bee Products on Quality and Safety Control, Wuhan 430070, China.
Hubei Provincial Institute for Food Supervision and Test, 430070, PR China.
出版信息
Food Chem. 2022 Sep 30;389:133071. doi: 10.1016/j.foodchem.2022.133071. Epub 2022 Apr 26.
Bee pollen, which is known as a "full-nutrient food", has outstanding anti-tyrosinase activity. However, the chemical components contributing to this activity remain unknown. To comprehensively elucidate the chemical components of bee pollen inhibiting tyrosinase, we performed the anti-tyrosinase activity evaluation of bee pollen extract (BPE) of eight species, metabolomic analysis of chemical composition, multivariate statistical analysis and correlation analysis. The results revealed that the anti-tyrosinase activity of eight BPEs was significantly different (p < 0.05), with IC value ranging from 10.08 to 408.81 μg/mL. A total of 725 metabolites were detected from these BPEs, and 40 differential metabolites were identified, all of which were phenolamides. All these phenolamides were positively correlated with the anti-tyrosinase activity, among which 26 phenolamides (21 spermidine derivatives and five spermine derivatives) showed particularly high correlations (r > 0.7). This is the first report to reveal the main contributor to the anti-tyrosinase activity of bee pollen.
蜂花粉，被誉为“全营养食品”，具有出色的酪氨酸酶抑制活性。然而，其具有该活性的化学组成部分尚不清楚。为了全面阐明抑制酪氨酸酶的蜂花粉的化学组成，我们对 8 种蜂花粉提取物（BPE）进行了酪氨酸酶抑制活性评价、化学成分的代谢组学分析、多元统计分析和相关分析。结果表明，8 种 BPE 的酪氨酸酶抑制活性差异显著（p<0.05），IC 值范围为 10.08 至 408.81μg/mL。从这些 BPE 中检测到 725 种代谢物，鉴定出 40 种差异代谢物，均为酚酰胺。所有这些酚酰胺与酪氨酸酶抑制活性呈正相关，其中 26 种酚酰胺（21 种亚精胺衍生物和 5 种精胺衍生物）相关性特别高（r>0.7）。这是首次报道揭示了蜂花粉抑制酪氨酸酶活性的主要贡献者。
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