Kim Hye Mi, Kim Ji Hoon, Jeon Je-Seung, Kim Chul Young
College of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University ERICA, Ansan 15588, Republic of Korea.
Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, Rural Development Administration (RDA), Eumseong 27709, Republic of Korea.
Molecules. 2025 May 12;30(10):2129. doi: 10.3390/molecules30102129.
Eggplants are high in polyphenols, making them a powerful antioxidant food that is beneficial for health and has excellent anti-aging effects. As metabolism slows down with aging, lipid peroxides are generated, with 2-nonenal being the main cause of old-age odor, which has a detrimental effect on skin keratinocytes. In this study, the 2-nonenal scavenging ability of fruits, leaves, stems, and roots of eggplant was evaluated, and the active compound was identified as --feruloylputrescine. Furthermore, we assessed whether the extracts and --feruloylputrescine showed a protective effect against skin damage induced by 2-nonenal. The antioxidant activity of the eggplant extracts was evaluated using DPPH and ABTS assays, and the fruits exhibited stronger antioxidant activity compared to the other extracts. Additionally, it was found that the ROS levels increased by 2-nonenal were significantly reduced by eggplant fruits and roots, which also inhibited lipid peroxidation. These results suggest the possibility of inhibiting the production of 2-nonenal itself. These findings suggest that eggplant extracts and the --feruloylputrescine can have a positive effect on preventing aging and maintaining skin health.
茄子富含多酚，使其成为一种强大的抗氧化食物，对健康有益且具有出色的抗衰老作用。随着年龄增长新陈代谢减缓，会产生脂质过氧化物，其中2-壬烯醛是老年气味的主要成因，对皮肤角质形成细胞有不利影响。在本研究中，评估了茄子果实、叶片、茎和根对2-壬烯醛的清除能力，并鉴定出活性化合物为阿魏酰腐胺。此外，我们评估了提取物和阿魏酰腐胺是否对2-壬烯醛诱导的皮肤损伤具有保护作用。使用DPPH和ABTS测定法评估茄子提取物的抗氧化活性，结果显示果实提取物比其他提取物表现出更强的抗氧化活性。此外，发现茄子果实和根显著降低了由2-壬烯醛增加的ROS水平，同时也抑制了脂质过氧化。这些结果提示了抑制2-壬烯醛自身产生的可能性。这些发现表明茄子提取物和阿魏酰腐胺对预防衰老和维持皮肤健康可能具有积极作用。
