Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Respir Investig. 2022 Jul;60(4):510-521. doi: 10.1016/j.resinv.2022.03.006. Epub 2022 Apr 26.
Chronic obstructive pulmonary disease (COPD) is a type of obstructive lung disease that is characterized by poor airflow and airway inflammation. It is estimated that the global prevalence of COPD is about 13.1%. Anemia is associated with increased morbidity and hospitalization duration. In this systematic review, we investigate the association between all types of anemia and COPD progression.
We systematically searched electronic databases, including Scopus, Medline/PubMed, EMBASE, Web of Sciences (WOS), and Cochrane Library, using the following mesh-standardized keywords: (((anemia∗ OR anaemia∗) OR "chronic anemia disease" [Mesh] OR "CAD" OR "iron deficiency anemia" OR" IDA" OR) AND ("COPD" [Mesh] OR "chronic obstructive pulmonary disease")) until February 2022.
Overall of 11,158 studies were included. Ultimately, 59 studies were included in the analysis. The most apparent findings from the analysis were that exacerbation of COPD, increased hospitalization, and increased long-term mortality were associated with anemia. Further analysis showed that iron deficiency (ID) is a common finding in COPD and is accompanied by an increase in the systolic pulmonary artery pressure.
Despite the comfortable control of anemia, the absence of treatment can be life-threatening in patients with COPD. Our systematic results showed significant homogeneity between studies on the increased mortality rate in anemic COPD, increased hospitalization, and decreased quality of life.
慢性阻塞性肺疾病（COPD）是一种阻塞性肺病，其特征是气流受限和气道炎症。据估计，全球 COPD 的患病率约为 13.1%。贫血与发病率和住院时间延长有关。在这项系统评价中，我们研究了所有类型的贫血与 COPD 进展之间的关系。
我们系统地检索了电子数据库，包括 Scopus、Medline/PubMed、EMBASE、Web of Sciences（WOS）和 Cochrane Library，使用以下标准化术语：（（（贫血或贫血）或“慢性贫血疾病”[Mesh]或“CAD”或“缺铁性贫血”或“IDA”）和（“COPD”[Mesh]或“慢性阻塞性肺疾病”））直到 2022 年 2 月。
共纳入 11158 项研究。最终，有 59 项研究纳入分析。分析中最明显的发现是 COPD 加重、住院增加和长期死亡率增加与贫血有关。进一步的分析表明，缺铁（ID）是 COPD 的常见表现，同时伴有收缩期肺动脉压升高。
尽管贫血得到了舒适的控制，但 COPD 患者不治疗可能会危及生命。我们的系统评价结果表明，贫血性 COPD 死亡率增加、住院增加和生活质量下降的研究之间存在显著的同质性。
