Wang Yong, Sun Zhongru, Zhou Zhijun
Department of Radiology, 372209Taizhou People's Hospital, Fifth Affiliated Hospital of Nantong University, Taizhou, Jiangsu, PR China.
Acta Radiol. 2023 Feb;64(2):784-791. doi: 10.1177/02841851221094967. Epub 2022 Apr 28.
Patients with Parkinson's disease (PD) have been documented with disrupted dynamic profiles of functional connectivity. However, the complementary information that is relevant to the dynamic pattern of global synchronization in patients with PD requires further investigation.
To reveal the aberrant dynamic profiles of global synchronization involved in PD with a focus on temporal variability, strength, and property.
A total of 46 patients with PD and 50 matched healthy controls (HCs) were enrolled. Degree centrality (DC) was used as the metric of global synchronization. The intergroup differences in the dynamic DC (dDC) pattern were compared, followed by further analysis of their clinical relevance in PD.
Relative to HCs, the PD group showed decreased dDC variability in right inferior occipital gyrus, right insula, right middle occipital gyrus (MOG), and bilateral postcentral gyrus. The dDC variability in the MOG was significantly correlated with MoCA score. Two states (state I and state II) were suggested. Relative to HCs, the PD group demonstrated a shorter mean dwell time (MDT) in state I, a longer MDT in state II, and fewer transitions. For the PD group, dDC properties were significantly correlated with UPDRS-III scores. In state II, significantly decreased dynamic dDC strength in bilateral supplementary motor area was observed in the PD group, with a significant correlation with UPDRS-III scores.
These findings on PD imply that dynamic alterations of global synchronization are engaged in the dysfunction of movement and cognition, deepening the understanding of deteriorations that underlie PD with complementary evidence.
帕金森病（PD）患者的功能连接动态特征已被证明存在破坏。然而，与PD患者全局同步动态模式相关的补充信息仍需进一步研究。
揭示PD患者中涉及的全局同步异常动态特征，重点关注时间变异性、强度和特性。
共纳入46例PD患者和50例匹配的健康对照（HCs）。中心性程度（DC）用作全局同步的指标。比较动态DC（dDC）模式的组间差异，随后进一步分析其在PD中的临床相关性。
相对于HCs，PD组在右侧枕下回、右侧岛叶、右侧枕中回（MOG）和双侧中央后回的dDC变异性降低。MOG中的dDC变异性与蒙特利尔认知评估量表（MoCA）评分显著相关。提出了两种状态（状态I和状态II）。相对于HCs，PD组在状态I的平均停留时间（MDT）较短，在状态II的MDT较长，且转换次数较少。对于PD组，dDC特性与统一帕金森病评定量表第三部分（UPDRS-III）评分显著相关。在状态II中，PD组双侧辅助运动区的动态dDC强度显著降低，与UPDRS-III评分显著相关。
这些关于PD的发现表明，全局同步的动态改变参与了运动和认知功能障碍，以补充证据加深了对PD潜在恶化的理解。
