血友病患者自发性脉络膜上腔出血与ChAdOx1 nCoV-19疫苗接种同时发生。
Spontaneous suprachoroidal haemorrhage in haemophilia coincident with ChAdOx1 nCoV-19 vaccine.
作者信息
Behera Geeta, Jossy Ajax, Deb Amit Kumar, Neelakandan Siddharth, Basavarajegowda Abhishek
机构信息
Department of Ophthalmology, Jawaharlal Institute of Post-Graduate Medical Education and Research (JIPMER), Puducherry, India.
Department of Internal Medicine, Jawaharlal Institute of Post-Graduate Medical Education and Research (JIPMER), Puducherry, India.
出版信息
Eur J Ophthalmol. 2023 Jul;33(4):NP59-NP61. doi: 10.1177/11206721221098207. Epub 2022 Apr 28.
PURPOSE
To report a case of spontaneous suprachoroidal haemorrhage in a haemophilia patient immediately following ChAdOx1 nCoV-19 vaccination.
CASE PRESENTATION
A 60-year-old man with haemophilia developed painful vision loss in his left eye a day following the ChAdOx1 nCoV-19 vaccination due to acute angle-closure glaucoma from a massive suprachoroidal haemorrhage. He had an extremely deranged coagulation profile; activated partial thromboplastin time (APTT): 89 s, normal range 29-35 s After factor VIII transfusion, ocular hypotensive therapy and systemic/topical steroids, the suprachoroidal haemorrhage and glaucoma resolved, but the vision remained poor.
CONCLUSION
Spontaneous suprachoroidal haemorrhage may be seen in haemophiliacs with deranged coagulation profiles. In our case, it followed ChAdOx1 nCoV-19 vaccination, and we recommend caution and checking the coagulation profile in such patients apriori.
目的
报告1例接种ChAdOx1 nCoV-19疫苗后立即发生自发性脉络膜上腔出血的血友病患者。
病例介绍
一名60岁的血友病男性在接种ChAdOx1 nCoV-19疫苗一天后，因大量脉络膜上腔出血导致急性闭角型青光眼，出现左眼疼痛性视力丧失。他的凝血指标严重紊乱；活化部分凝血活酶时间（APTT）：89秒，正常范围29 - 35秒。输注凝血因子VIII、进行降眼压治疗以及全身/局部使用类固醇后，脉络膜上腔出血和青光眼得到缓解，但视力仍较差。
结论
凝血指标紊乱的血友病患者可能会出现自发性脉络膜上腔出血。在我们的病例中，这种情况发生在接种ChAdOx1 nCoV-19疫苗之后，我们建议对此类患者事先谨慎并检查其凝血指标。
Zotero 插件