Kerby G R, Mayer L S, Pingleton S K
Am Rev Respir Dis. 1987 Mar;135(3):738-40. doi: 10.1164/arrd.1987.135.3.738.
Five patients with chronic respiratory failure from neuromuscular disease and symptomatic worsening nocturnal hypoventilation were treated with nocturnal ventilation. Home ventilation at night was provided by a volume-cycled positive pressure ventilator attached to a nasal mask originally designed to administer nasal continuous positive airway pressure (CPAP) for obstructive sleep apnea. The device was well tolerated. Symptoms of headache, insomnia/somnolence, and impaired intellectual capacity rapidly disappeared with nocturnal ventilatory support. Daytime arterial PO2 and PCO2 improved after therapy. There are several advantages over commonly used, negative pressure devices for nocturnal ventilation. These include patient synchronization of tidal volume, ease of application, less cumbersome apparatus, more nocturnal patient mobility, and absence of production of upper airway obstruction.
5例因神经肌肉疾病导致慢性呼吸衰竭且夜间低通气症状加重的患者接受了夜间通气治疗。夜间家庭通气由一台容积控制型正压通气机提供，该通气机连接到一个最初设计用于阻塞性睡眠呼吸暂停的鼻持续气道正压通气（CPAP）的鼻罩上。该设备耐受性良好。夜间通气支持后，头痛、失眠/嗜睡和智力受损等症状迅速消失。治疗后白天动脉血氧分压（PO2）和二氧化碳分压（PCO2）有所改善。与常用的夜间通气负压设备相比，有几个优点。这些优点包括潮气量与患者同步、易于应用、设备更轻便、患者夜间活动能力更强以及不会产生上气道阻塞。
