Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Science and Chemical Engineering, Harbin Engineering University, Harbin, 150001, P. R. China.
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.
Small. 2018 Mar;14(13):e1703809. doi: 10.1002/smll.201703809. Epub 2018 Feb 2.
Here a multifunctional nanoplatform (upconversion nanoparticles (UCNPs)-platinum(IV) (Pt(IV))-ZnFe O , denoted as UCPZ) is designed for collaborative cancer treatment, including photodynamic therapy (PDT), chemotherapy, and Fenton reaction. In the system, the UCNPs triggered by near-infrared light can convert low energy photons to high energy ones, which act as the UV-vis source to simultaneously mediate the PDT effect and Fenton's reaction of ZnFe O nanoparticles. Meanwhile, the Pt(IV) prodrugs can be reduced to high virulent Pt(II) by glutathione in the cancer cells, which can bond to DNA and inhibit the copy of DNA. The synergistic therapeutic effect is verified in vitro and in vivo results. The cleavage of Pt(IV) from UCNPs during the reduction process can shift the larger UCPZ nanoparticles (NPs) to the smaller ones, which promotes the enhanced permeability and retention (EPR) and deep tumor penetration. In addition, due to the inherent upconversion luminescence (UCL) and the doped Yb and Fe in UCPZ, this system can serve as a multimodality bioimaging contrast agent, covering UCL, X-ray computed tomography, magnetic resonance imaging, and photoacoustic. A smart all-in-one imaging-guided diagnosis and treatment system is realized, which should have a potential value in the treatment of tumor.
这里设计了一种多功能纳米平台（上转换纳米粒子（UCNPs）-铂（IV）（Pt（IV））-ZnFe O，记为 UCPZ），用于协同癌症治疗，包括光动力疗法（PDT）、化学疗法和芬顿反应。在该系统中，近红外光触发的 UCNPs 可以将低能量光子转化为高能量光子，作为 UV-vis 光源，同时介导 ZnFe O 纳米粒子的 PDT 效应和芬顿反应。同时，谷胱甘肽可以将 Pt（IV）前药还原为高毒性的 Pt（II），与 DNA 结合并抑制 DNA 的复制。协同治疗效果在体外和体内得到了验证。还原过程中 UCNPs 从 Pt（IV）的裂解可以将较大的 UCPZ 纳米颗粒（NPs）转移到较小的颗粒，从而促进增强的通透性和保留（EPR）和深肿瘤渗透。此外，由于 UCPZ 中固有的上转换发光（UCL）和掺杂的 Yb 和 Fe，该系统可以作为一种多模态生物成像造影剂，涵盖 UCL、X 射线计算机断层扫描、磁共振成像和光声。实现了一种智能的一体化成像引导诊断和治疗系统，在肿瘤治疗中具有潜在价值。
