Department of Emergency Medicine, Çanakkale Onsekiz Mart University Faculty of Medicine, Çanakkale-Turkey.
Department of Internal Medicine, Çanakkale Onsekiz Mart University Faculty of Medicine, Çanakkale-Turkey.
Ulus Travma Acil Cerrahi Derg. 2022 Mar;28(3):268-275. doi: 10.14744/tjtes.2020.26348.
The neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte-ratio (PLR), and red blood cell distribution width (RDW) are simple indicators of inflammatory status previously established as a severity indicator in distinct disease states. This study aimed to determine the impact of these simple hematologic indices with conventional inflammation markers such as C-reactive pro-tein (CRP) and white blood cells in acute pancreatitis (AP) patients and their relationship with AP risk stratification scores including Bedside Index for Severity of Acute Pancreatitis (BISAP) and modified Glaskow Prognostic score (mGPS) scores.
This retrospective study was performed in the emergency department of Canakkale Onsekiz Mart University. A total of 171 patients (male/female: 68 [39.8%]/103 [60.3%]) with AP and 59 age and gender matched healthy subjects (male/female: 23 [39%]/36[61%]) as controls were enrolled in the present study. The patients were grouped according to severity and adverse outcomes according to BISAP and mGPS and a comparative analysis was performed to compare the NLR, PLR, and RDW between groups.
The mean NLR values of AP patients and control group were 9.62±6.34 and 2.04±1.08, respectively (p<0.001), while the mean PLR values of AP patients and control group were 221.83±122.43 and 83.30±38.89, respectively (p<0.001). Except from RDW, all the other hematologic indices were found to be elevated (p<0.05 for WBC; NLR, PLR, and CRP) on both mild and severe disease at disease onset. NLR and PLR showed significant predictive ability for estimating serious complications associated with AP.
The present study showed that NLR and PLR is increased in AP. Moreover, peripheral blood NLR and PLR values can predict disease severity and adverse outcomes associated with AP and can be used as an adjunctive marker for estimating disease severity.
中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）和红细胞分布宽度（RDW）是先前在不同疾病状态下被确立为严重程度指标的炎症状态的简单指标。本研究旨在确定这些简单的血液学指标与 C 反应蛋白（CRP）和白细胞等常规炎症标志物在急性胰腺炎（AP）患者中的影响，及其与包括床边严重程度指数（BISAP）和改良格拉斯哥预后评分（mGPS）在内的 AP 风险分层评分的关系。
本回顾性研究在 Canakkale Onsekiz Mart 大学的急诊部门进行。共纳入 171 名 AP 患者（男/女：68 [39.8%]/103 [60.3%]）和 59 名年龄和性别匹配的健康对照者（男/女：23 [39%]/36 [61%]）。根据 BISAP 和 mGPS 将患者分为严重程度和不良结局组，并对各组之间 NLR、PLR 和 RDW 进行比较分析。
AP 患者和对照组的平均 NLR 值分别为 9.62±6.34 和 2.04±1.08（p<0.001），而 AP 患者和对照组的平均 PLR 值分别为 221.83±122.43 和 83.30±38.89（p<0.001）。除 RDW 外，在疾病发作时，所有其他血液学指标（白细胞计数、NLR、PLR 和 CRP）均升高（轻度和重度疾病均为 p<0.05）。NLR 和 PLR 显示出对估计与 AP 相关的严重并发症有显著的预测能力。
本研究表明，AP 中 NLR 和 PLR 升高。此外，外周血 NLR 和 PLR 值可预测 AP 的严重程度和不良结局，并可作为评估疾病严重程度的辅助标志物。
