中性粒细胞与淋巴细胞比值对预测急性胰腺炎严重程度的诊断价值：一项荟萃分析。
Diagnostic Value of Neutrophil-Lymphocyte Ratio for Predicting the Severity of Acute Pancreatitis: A Meta-Analysis.
机构信息
Department of Emergency Surgery, Department of Emergency Medicine, The First Affiliated Hospital of Anhui Medical University, Heifei, China.
Department of Emergency Internal Medicine, Department of Emergency Medicine, The First Affiliated Hospital of Anhui Medical University, Heifei, China.
出版信息
Dis Markers. 2020 Apr 27;2020:9731854. doi: 10.1155/2020/9731854. eCollection 2020.
BACKGROUND
Acute pancreatitis (AP) is a life-threatening disease caused by a variety of factors, and once it progresses to severe acute pancreatitis, the prognosis is poor. The purpose of this study was to investigate the diagnostic value of the neutrophil-lymphocyte ratio (NLR) for predicting the severity of acute pancreatitis.
MATERIALS AND METHODS
We searched the databases of PubMed, EMBASE, Web of Science, and Cochrane Library to identify eligible studies using the NLR to predict the severity of AP. The sensitivity (SEN), specificity (SPE), negative likelihood ratio (NLR), positive likelihood ratio (PLR), diagnostic odds ratio (DOR), and area under the receiver operating characteristic curve (AUC) were combined using a bivariate mixed model.
RESULTS
A total of 10 articles containing 394 cases and 1319 controls were included in the study. The combined SEN, SPE, NLR, PLR, DOR, and AUC are 79% (73%-84%), 71% (59%-80%), 0.30 (0.21-0.41), 2.7 (1.8-4.0), 9 (5-18), and 0.82 (0.78-0.85), respectively.
CONCLUSIONS
NLR has a moderately high diagnostic value in predicting the severity of acute pancreatitis.
背景
急性胰腺炎（AP）是一种由多种因素引起的危及生命的疾病，一旦发展为重症急性胰腺炎，预后较差。本研究旨在探讨中性粒细胞-淋巴细胞比值（NLR）预测急性胰腺炎严重程度的诊断价值。
材料与方法
我们检索了 PubMed、EMBASE、Web of Science 和 Cochrane Library 数据库，使用 NLR 预测 AP 严重程度的合格研究。使用双变量混合模型合并敏感性（SEN）、特异性（SPE）、阴性似然比（NLR）、阳性似然比（PLR）、诊断比值比（DOR）和受试者工作特征曲线下面积（AUC）。
结果
共有 10 篇文章纳入 394 例病例和 1319 例对照。合并的 SEN、SPE、NLR、PLR、DOR 和 AUC 分别为 79%（73%-84%）、71%（59%-80%）、0.30（0.21-0.41）、2.7（1.8-4.0）、9（5-18）和 0.82（0.78-0.85）。
结论
NLR 对预测急性胰腺炎严重程度具有中等高度的诊断价值。
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