Faculty of Science, Universiti Brunei Darussalam, Jln Tungku Link, Brunei Darussalam.
Institute of Applied Data Analytics, Universiti Brunei Darussalam, Jln Tungku Link, Brunei Darussalam.
Asian Pac J Cancer Prev. 2022 Apr 1;23(4):1415-1423. doi: 10.31557/APJCP.2022.23.4.1415.
This study provides population-based study of cancer incidence, mortality and survival rates for women diagnosed with epithelial ovarian cancer (EOC), and evaluate the prognostic factors of EOC patients survival in Brunei Darussalam.
This is a retrospective study of patients diagnosed with EOC between 1st January 2007 and 31st December 2017 in Brunei Darussalam. Crude, age-specific, age-standardized incidence and mortality rates per 100,000 women were calculated. Kaplan-Meier method was used to determine the overall 5-years survival rate. Log-rank test was used to examine the differences in survival between groups. The multivariable Cox Proportional Hazard regression models were used to estimate the hazard ratio for overall survival and to identify the prognostic factors.
A total of 207 patients were included in the study. The crude incidence and mortality rates were 9.7 and 3.6 per 100,000 respectively while the age-standardized incidence and mortality rates were 11.3 (95% CI: 9.7,12.9) and 4.5 (95% CI: 3.4,5.6) per 100,000 respectively in the period 2007-2017. The overall mean age at diagnosis was 48.4 (standard deviation=15.3) years. The overall survival rates at 1, 3, and 5 years for EOC patients were 79.7%, 69.7%, and 61.4% respectively. Age at diagnosis, cancer stage, and histology were significant prognostic factors for patients' survival. Older age at diagnosis (≥70 years vs <40 years), regional or advanced stage (vs localized stage) and having undifferentiated or other epithelial ovarian (vs serous carcinoma) were associated with having higher hazard of death.
Early detection of disease should be emphasized through public education and raising awareness to improve survival rates of patients with EOC.
本研究提供了在文莱达鲁萨兰国诊断为上皮性卵巢癌（EOC）的女性的癌症发病率、死亡率和生存率的基于人群的研究，并评估了 EOC 患者生存的预后因素。
这是一项在文莱达鲁萨兰国 2007 年 1 月 1 日至 2017 年 12 月 31 日期间诊断为 EOC 的患者的回顾性研究。计算了每 10 万名女性的粗发病率、年龄特异性发病率、年龄标准化发病率和死亡率。使用 Kaplan-Meier 方法确定总 5 年生存率。对数秩检验用于检查组间生存差异。多变量 Cox 比例风险回归模型用于估计总生存率的风险比，并确定预后因素。
本研究共纳入 207 名患者。2007-2017 年期间，粗发病率和死亡率分别为 9.7 和 3.6/10 万，年龄标准化发病率和死亡率分别为 11.3（95%CI：9.7，12.9）和 4.5（95%CI：3.4，5.6）/10 万。诊断时的平均年龄为 48.4 岁（标准差=15.3）。EOC 患者的总体生存率在 1、3 和 5 年时分别为 79.7%、69.7%和 61.4%。诊断时的年龄、癌症分期和组织学是患者生存的重要预后因素。诊断时年龄较大（≥70 岁 vs <40 岁）、区域性或晚期（vs 局限性）以及未分化或其他上皮性卵巢癌（vs 浆液性癌）与死亡风险更高相关。
应通过公众教育和提高认识来强调疾病的早期发现，以提高 EOC 患者的生存率。
