Junlebao Dairy Group Co., Ltd., Shijiazhuang, Hebei, P. R. China.
Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Lett Appl Microbiol. 2022 Aug;75(2):330-337. doi: 10.1111/lam.13729. Epub 2022 May 9.
Colonization and development of gut microbiota during early life stage plays a key regulatory role in the establishment of the host-microbial relationship, which was conducive to progressing host immunity and maintaining health throughout the adulthood life span. This study was aimed to evaluate the protective effect from inflammatory bowel disease (IBD) in adulthood based on the early intervention of Lactobacillus paracasei N1115 (LP N1115). LP N1115 treatment was carried out during 2 weeks in postnatal mice. Then the dextran sodium sulphate (DSS)-induced colitis model mice were established in adulthood, and the status of intestinal tissues was detected. Results showed the decreased severity of intestinal tissue injury, cell apoptosis, and proinflammatory cytokines expression in DSS-induced model with LP N1115 early intervention. Therefore, the intake of LP N1115 in neonatal mice has played a long-term healthy role in the prevention of intestinal injury and inflammation in adulthood.
生命早期阶段肠道微生物群的定植和发展对宿主-微生物关系的确立起着关键的调节作用，这有利于促进宿主免疫，并在整个成年期保持健康。本研究旨在评估早期干预乳酸杆菌 N1115（LP N1115）对成年期炎症性肠病（IBD）的保护作用。在新生小鼠中进行 LP N1115 处理 2 周。然后在成年期建立葡聚糖硫酸钠（DSS）诱导的结肠炎模型小鼠，并检测肠道组织的状态。结果表明，早期干预 LP N1115 可降低 DSS 诱导模型中肠道组织损伤、细胞凋亡和促炎细胞因子表达的严重程度。因此，新生期摄入 LP N1115 对成年期肠道损伤和炎症的预防具有长期的健康作用。
