Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.
Canada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, BC, V5Z 1L3, Canada.
Biol Futur. 2022 Jun;73(2):157-169. doi: 10.1007/s42977-022-00119-2. Epub 2022 Apr 29.
GABARAPL2 was initially characterized for its involvement in protein transport and membrane fusion events, but has since gained notoriety for its role in autophagy. GABARAPL2 is frequently studied alongside its GABARAP subfamily members, GABARAP and GABARAPL1. Although functional redundancy exists among the subfamily members, a complex network of molecular interactions, physiological processes and pathologies can be primarily related to GABARAPL2. GABARAPL2 has a multifaceted role, ranging from cellular differentiation to intracellular degradation. Much of what we know about GABARAPL2 is gained through identifying its interacting partners-a list that is constantly growing. In this article, we review both the autophagy-dependent and autophagy-independent roles of GABARAPL2, and emphasize their implications for both health and disease.
GABARAPL2 最初因其参与蛋白质运输和膜融合事件而被描述，但后来因其在自噬中的作用而声名狼藉。GABARAPL2 经常与它的 GABARAP 亚家族成员 GABARAP 和 GABARAPL1 一起研究。尽管亚家族成员之间存在功能冗余，但一个复杂的分子相互作用网络、生理过程和病理学主要与 GABARAPL2 相关。GABARAPL2 具有多方面的作用，从细胞分化到细胞内降解。我们对 GABARAPL2 的了解很大程度上是通过确定其相互作用伙伴来获得的——这个列表还在不断增加。在本文中，我们综述了 GABARAPL2 的自噬依赖性和非依赖性作用，并强调了它们对健康和疾病的影响。
