Ferulic acid - A novel topical agent in reducing signs of photoaging.

Continuous production of reactive oxygen species, induced by UV radiation, is one of the main mechanisms contributing to skin photoaging. Therefore, the use of novel superior antioxidants, which ferulic acid belongs to, is an innovative treatment option. The aim of this study was to evaluate the effect of 14% ferulic acid peel on skin hydration, topography, the level of melanin, and the severity of erythema, in people with skin photoaging symptoms. Twenty women aged 45-60, received eight treatments of chemical peeling in 1-week intervals. Efficacy was measured using The Multi Probe Adapter (MPA) Systems (Courage + Khazaka electronic GmbH, Köln, Germany). The measurements were taken before, 8, and 12 weeks after the first treatment. Additionally, the photo documentation was made with Fotomedicus (Elfo) and VISIA® Complexion Analysis System (Canfield Scientific, Inc.). The objective evaluation showed statistically significant improvement in all measured skin parameters p < 0.05). The best results of skin hydration and melanin level were observed right after the end of the series (p < 0.001). The best improvement in erythema reduction was noted a month after the last treatment (p < 0.0001). At the control, untreated point none of the probes showed statistically significant changes. In conclusion, a series of treatments with 14% ferulic acid peel has a significant bleaching, erythema-reducing, and moisturizing activity. The results achieved by apparatus, are reflected by photo documentation. The effects achieved during a series persist over time.