Kołodziejczak Anna, Rotsztejn Helena
Department of Cosmetology and Aesthetic Dermatology, Medical University of Lódź, Łódź, Poland.
Clin Cosmet Investig Dermatol. 2024 Aug 23;17:1875-1885. doi: 10.2147/CCID.S469708. eCollection 2024.
Particular attention is given to the enhancement of melanin-related pigmentation (dark circles, photoaging) and vascular circles, which are commonly located in the tear trough. The objective of the study is to provide an objective evaluation of the impact of carboxytherapy and the treatment regimen combining carboxytherapy with lactobionic acid (20%, pH 2.1) or ferulic acid (14%, pH 4.0-5.0) and ascorbic acid (12%) on skin defects in the eye area.
A group of 39 Caucasian people were subjected to a series of five carboxytherapy treatments (right eye area) and five treatments combining carboxytherapy with a selected chemical peel for the skin around the eyes (left eye area). The efficacy of therapy was assessed based on parameters (MI and EI) measured with the Mexameter probe. Measurements were made in the tear trough and the middle of the lower eyelid.
We demonstrated that a series of carboxytherapy (right side) significantly statistically influenced the EI parameter (in different measurement points: P <0.0001, P = 0.015, P = 0.002), which reflects the intensity of vascular circles under the eyes. Improvement of this parameter by 7.2 units was also shown in the tear trough in 82.1% of participants after the application of carboxytherapy combined with acids (left side) on the valley of tears for this parameter (EI). Lactobionic acid and carboxytherapy were associated with a statistically significant improvement (P = 0.011) in the tear trough. In this study, a reduction in the combined pigmentation (MI plus EI) for both the right and left sides (p = 0.001 and p = 0.015, respectively) was observed.
The study provides objective evidence for the effectiveness of sole carboxytherapy and carboxytherapy combined with acids in the reduction of dark circles, in particular vascular circles in the tear trough. Lactobionic acid, ferulic acid, and ascorbic acid can be used as safe supplements to enhance carboxytherapy.
特别关注黑色素相关色素沉着（黑眼圈、光老化）和血管性黑眼圈的改善，这些问题通常出现在泪沟部位。本研究的目的是客观评估羧基疗法以及羧基疗法与乳糖酸（20%，pH 2.1）或阿魏酸（14%，pH 4.0 - 5.0）和抗坏血酸（12%）联合治疗方案对眼部皮肤缺陷的影响。
一组39名白种人接受了一系列五次羧基疗法治疗（右眼区域）以及五次将羧基疗法与眼部周围皮肤选择的化学换肤联合的治疗（左眼区域）。基于用Mexameter探头测量的参数（MI和EI）评估治疗效果。测量在泪沟和下眼睑中部进行。
我们证明，一系列羧基疗法（右侧）对EI参数有显著统计学影响（在不同测量点：P <0.0001，P = 0.015，P = 0.002），该参数反映了眼下血管性黑眼圈的强度。在泪沟部位，82.1%的参与者在将羧基疗法与酸联合应用（左侧）于泪沟后，该参数（EI）提高了7.2个单位。乳糖酸和羧基疗法在泪沟部位有统计学显著改善（P = 0.011）。在本研究中，观察到左右两侧的联合色素沉着（MI加EI）均有降低（分别为p = 0.001和p = 0.015）。
该研究为单独的羧基疗法以及羧基疗法与酸联合在减少黑眼圈，特别是泪沟部位的血管性黑眼圈方面的有效性提供了客观证据。乳糖酸、阿魏酸和抗坏血酸可用作增强羧基疗法的安全补充剂。
