Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.
Center for Transyouth Health and Development, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Trends Pharmacol Sci. 2022 Jul;43(7):582-592. doi: 10.1016/j.tips.2022.03.006. Epub 2022 Apr 26.
Transgender medicine is a diverse and growing clinical field with unmet gaps in pharmacological knowledge. Hormone therapy (testosterone or estrogen treatment), one part of the standard of medical care for transgender adults, aligns secondary sex characteristics with an individual's gender identity and expression. Despite established effects of sex steroids on drug-metabolizing enzyme expression and activity in vitro and in animal models, the effect of long-term, supraphysiological sex hormone treatment on drug metabolism in transgender adults is not yet established. Here, we synthesize available in vitro and animal model data with pharmacological concepts in transgender medicine to predict potential effects of sex steroids on drug-metabolizing enzymes, and their relationship with potential hormone-drug interactions, in transgender medicine.
跨性别医学是一个多样化且不断发展的临床领域，在药理学知识方面存在未满足的差距。激素治疗（睾酮或雌激素治疗）是跨性别成年人标准医疗护理的一部分，它使第二性特征与个体的性别认同和表达相一致。尽管体外和动物模型已经证实了性激素对药物代谢酶表达和活性的影响，但长期、超生理性激素治疗对跨性别成年人药物代谢的影响尚未确定。在这里，我们综合了可用的体外和动物模型数据以及跨性别医学中的药理学概念，以预测性激素对药物代谢酶的潜在影响，以及它们与潜在的激素-药物相互作用的关系。
