硫唑嘌呤和6-巯基嘌呤（6-MP）通过不同机制抑制人类混合淋巴细胞反应（MLR）。
Azathioprine and 6-mercaptopurine (6-MP) suppress the human mixed lymphocyte reaction (MLR) by different mechanisms.
作者信息
Al-Safi S A, Maddocks J L
出版信息
Br J Clin Pharmacol. 1984 Apr;17(4):417-22. doi: 10.1111/j.1365-2125.1984.tb02366.x.
Abstract
6-MP inhibitory effects on the MLR were reversed by AIC (46%), adenine (32%), hypoxanthine (89%), adenosine (86%) and inosine (93%). AIC, adenine, hypoxanthine and inosine had no effect on azathioprine inhibition of the MLR. Adenosine at 10 microM caused 29% reversal and had no effect at 100-400 microM on azathioprine inhibition of the MLR. Reversal of 6-MP suppression of the MLR was decreased with the delay of adenosine addition. Guanine, xanthine and guanosine caused no reversal of 6-MP or azathioprine inhibitory effects on the MLR. These results show that azathioprine and 6-MP suppress the MLR by different mechanisms.
摘要
AIC（46%）、腺嘌呤（32%）、次黄嘌呤（89%）、腺苷（86%）和肌苷（93%）可逆转6-巯基嘌呤对混合淋巴细胞反应（MLR）的抑制作用。AIC、腺嘌呤、次黄嘌呤和肌苷对硫唑嘌呤抑制MLR没有影响。10微摩尔的腺苷可导致29%的逆转，而在100 - 400微摩尔时对硫唑嘌呤抑制MLR没有影响。随着腺苷添加时间的延迟，6-巯基嘌呤对MLR抑制作用的逆转程度降低。鸟嘌呤、黄嘌呤和鸟苷不会逆转6-巯基嘌呤或硫唑嘌呤对MLR的抑制作用。这些结果表明，硫唑嘌呤和6-巯基嘌呤通过不同机制抑制MLR。
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