Department of Neurosurgery, 221266Bezmialem Vakif University, Istanbul, Turkey.
Equal contribution.
Neuroradiol J. 2022 Dec;35(6):763-767. doi: 10.1177/19714009221096836. Epub 2022 Apr 29.
Metastasis of a systemic tumor into a primary brain tumor has been rarely reported in the literature. These metastases could be seen mostly in meningiomas and in less frequently in the other intracranial tumors. Carcinoma of an unknown primary site (CUP) metastasizing into an intracranial meningioma is not a common occasion. According to the best of our knowledge, in this report, we present the first case with multiple recurrent CUP, which metastasized to intracranial meningioma, reported in the literature. The whole body was investigated with FDG PET/CT and biomarkers of the most common carcinomas for primary cancer. However, these tests showed no primary affected region. Despite all adjuvant therapies, the tumor had multiple recurrences. Such cases are still a challenge to offer optimal management.
文献中鲜有系统性肿瘤转移至原发性脑肿瘤的报道。这些转移瘤大多可见于脑膜瘤，少见情况下也可见于其他颅内肿瘤。原发灶不明的癌（CUP）转移至颅内脑膜瘤并不常见。据我们所知，在本报告中，我们首次报道了一例多发复发性 CUP 转移至颅内脑膜瘤的病例。全身 FDG PET/CT 和最常见的原发性癌症生物标志物均进行了检查，但这些检查均未发现原发性受累区域。尽管采用了所有辅助治疗，肿瘤仍多次复发。对于此类病例，提供最佳治疗方案仍然是一项挑战。
