Neville Iuri Santana, Solla Davi Fontoura, Oliveira Arthur Maynart, Casarolli Cesar, Teixeira Manoel Jacobsen, Paiva Wellingson Silva
Division of Neurological Surgery, University of Sao Paulo Medical School, Sao Paulo, SP 05403010, Brazil.
Oncol Lett. 2017 Mar;13(3):1529-1534. doi: 10.3892/ol.2017.5655. Epub 2017 Jan 27.
Tumor-to-meningioma metastasis (TMM) is a fairly uncommon phenomenon. Only 7 cases of prostate cancer with TMM have previously been described in the literature. The present study aimed to report a case of prostate cancer TMM, and to discuss the relevant clinical and neuroimaging aspects of this condition. A 68-year-old patient presented with headaches, poor visual acuity in the left eye and ipsilateral eyelid droop 3 years after a Simpson II resection of a left sphenoid wing meningioma. Computed tomography revealed a hyperdense area suggestive of a recurrent left sphenoid wing meningioma. During microsurgical resection of tumor, the tumor presented a fibrous aspect and bled profusely. In the histological examination, a metastatic adenocarcinoma was identified inside the transitional meningioma. The immunohistochemical exam favored a prostatic primary site. The patient died two months later of septic shock from pneumonia. This is a rare metastatic presentation. The pre-operative diagnosis of TMM remains challenging in the majority of cases.
肿瘤向脑膜瘤转移（TMM）是一种相当罕见的现象。此前文献中仅描述过7例前列腺癌发生TMM的病例。本研究旨在报告1例前列腺癌TMM病例，并探讨该病症相关的临床和神经影像学方面。一名68岁患者在左侧蝶骨嵴脑膜瘤进行辛普森II级切除术后3年，出现头痛、左眼视力下降和同侧眼睑下垂。计算机断层扫描显示一个高密度区域，提示左侧蝶骨嵴脑膜瘤复发。在肿瘤的显微手术切除过程中，肿瘤呈纤维状外观且出血量大。在组织学检查中，在过渡性脑膜瘤内发现了转移性腺癌。免疫组化检查支持原发部位为前列腺。该患者两个月后死于肺炎引起的感染性休克。这是一种罕见的转移表现。在大多数病例中，TMM的术前诊断仍然具有挑战性。
