20 年后成年人群样本中酒精依赖严重程度与死亡率的关系。
Severity of alcohol dependence and mortality after 20 years in an adult general population sample.
机构信息
Department of Prevention Research and Social Medicine, Institute of Community Medicine, University Medicine Greifswald, Greifswald, Germany.
German Center for Cardiovascular Research, Greifswald, Germany.
出版信息
Int J Methods Psychiatr Res. 2022 Sep;31(3):e1915. doi: 10.1002/mpr.1915. Epub 2022 Apr 29.
OBJECTIVES
To estimate mortality on grounds of the severity of alcohol dependence which has been assessed by two approaches: the frequency of alcohol dependence symptoms (FADS) and the number of alcohol dependence criteria (NADC).
METHODS
A random sample of adult community residents in northern Germany at age 18 to 64 had been interviewed in 1996. Among 4075 study participants at baseline, for 4028 vital status was ascertained 20 years later. The FADS was assessed by the Severity of Alcohol Dependence Scale among the 780 study participants who had one or more symptoms of alcohol dependence or abuse and vital status information. The NADC was estimated by the Munich Composite International Diagnostic Interview among 4028 study participants with vital status information. Cox proportional hazard models were used.
RESULTS
The age-adjusted hazard ratio for the FADS (value range: 0-79) was 1.02 (95% confidence interval, CI: 1.016-1.028), for the NADC (value range: 0-7) it was 1.25 (CI: 1.19-1.32).
CONCLUSIONS
The FADS and NADC predicted time to death in a dose-dependent manner in this adult general population sample.
目的
通过两种方法（酒精依赖症状的频率[FADS]和酒精依赖标准的数量[NADC]）评估酒精依赖严重程度，估算死亡率。
方法
1996 年，德国北部对随机抽取的年龄在 18 至 64 岁的成年社区居民进行了访谈。在基线时的 4075 名研究参与者中，20 年后有 4028 人确定了生存状况。在有 1 个或多个酒精依赖或滥用症状且有生存状况信息的 780 名研究参与者中，使用酒精依赖严重程度量表评估 FADS。在有生存状况信息的 4028 名研究参与者中，使用慕尼黑综合国际诊断访谈评估 NADC。使用 Cox 比例风险模型。
结果
年龄调整后的 FADS（数值范围：0-79）风险比为 1.02（95%置信区间，CI：1.016-1.028），NADC（数值范围：0-7）的风险比为 1.25（CI：1.19-1.32）。
结论
在该成年普通人群样本中，FADS 和 NADC 以剂量依赖性方式预测死亡时间。
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