Department of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand.
Samitivej Esthetic Institute, Samitivej Sukhumvit Hospital, Bangkok, Thailand.
J Cosmet Dermatol. 2022 Jul;21(7):2832-2839. doi: 10.1111/jocd.15031. Epub 2022 May 16.
Removal of the unwanted tattoo was initially focused treatment of picosecond laser in the setting of the unfractionated beam, whereas the fractionated 1064-nm picosecond lasers (Fr-Pico) has been successfully utilized in various skin conditions, including scar and benign pigmented lesions. However, no studies compared the combination of Fr-Pico and unfractional 1064-nm picosecond laser (UFr-Pico) and UFr-Pico alone in tattoo removal.
This study aims to compare the efficacy and safety of the combination of Fr-Pico and UFr-Pico and the UFr-Pico and in tattoo removal.
Nineteen black tattoos in 11 patients were treated with UFr-Pico on one half and in combination with Fr-Pico on another half over three sessions with 4-week intervals and 4-week follow-up after the last session. Treatment efficacy was assessed using digital photographs, skin imaging analysis, and patient satisfaction.
After three treatments, tattoo clearance scores revealed that greater than 50% clearance was achieved in 11 (84.6%) tattoos treated with combination side and 9 (69.2%) tattoos with UFr-Pico alone. Significant differences were observed between the groups at 8 and 12 weeks. Skin textural changes also demonstrated significant improvements in the combination side at Week 12. Adverse events, such as blistering and textural changes, were fewer in the combination side.
The combination of 1064 nm Fr-Pico and UFr-Pico may be more effective and safer in tattoo removal than UFr-Pico alone.
最初，去除不需要的纹身主要集中在非分段光束的皮秒激光治疗上，而分段 1064nm 皮秒激光（Fr-Pico）已成功应用于各种皮肤状况，包括疤痕和良性色素病变。然而，目前尚无研究比较 Fr-Pico 联合非分段 1064nm 皮秒激光（UFr-Pico）与单纯 UFr-Pico 在纹身去除中的疗效。
本研究旨在比较 Fr-Pico 联合 UFr-Pico 与单纯 UFr-Pico 在纹身去除中的疗效和安全性。
11 名患者的 19 个黑色纹身，每半部分分别采用 UFr-Pico 和 Fr-Pico 联合治疗，每半部分治疗 3 次，间隔 4 周，末次治疗后 4 周进行随访。采用数字照片、皮肤成像分析和患者满意度评估治疗效果。
经过 3 次治疗后，根据纹身清除评分，联合治疗组有 11 个（84.6%）纹身和 UFr-Pico 单独治疗组的 9 个（69.2%）纹身达到>50%的清除率。组间在 8 周和 12 周时差异具有统计学意义。在 12 周时，皮肤纹理变化也显示联合治疗组有显著改善。联合治疗组的不良反应（如水疱和纹理改变）较少。
1064nm Fr-Pico 联合 UFr-Pico 治疗纹身比单纯 UFr-Pico 治疗更有效、更安全。
