Collins J P, Lewandowski B J
Br J Urol. 1987 Jan;59(1):84-8. doi: 10.1111/j.1464-410x.1987.tb04587.x.
We present our experience with the intracorporeal injection of papaverine and duplex sonography in the assessment of 47 patients with suspected vasculogenic impotence. Sonography and Doppler analysis were performed before and after the papaverine injection. The anatomy of the penis was easily seen. Flow in the deep arteries was obtained in most patients in both the flaccid and erect state. Patients with a good erectile response to papaverine injection had a larger increase in the inner diameter of the deep cavernosal artery than did those with a poor response. However, the percentage change in the diameter did not correlate with the degree of clinical response. Following injection, the systolic peak flow rates and diastolic minimum flow rates were higher in patients with some clinical response but only the increase in diastolic flow rates correlated in a stepwise fashion with the degree of clinical response. This technique provides a method for the objective assessment of response to intracorporeal papaverine injection. Its potential as a diagnostic test will only be determined after normal values are established. At present it appears most useful in patients responding poorly to papaverine injection by indicating the possible area of vascular impairment and the direction for further evaluation.
我们介绍了对47例疑似血管性阳痿患者进行罂粟碱体内注射及双功超声检查的经验。在罂粟碱注射前后均进行了超声检查和多普勒分析。阴茎的解剖结构清晰可见。大多数患者在疲软和勃起状态下均能获得海绵体深动脉的血流情况。对罂粟碱注射勃起反应良好的患者，其海绵体深动脉内径的增加幅度大于反应不佳者。然而，直径的百分比变化与临床反应程度并无相关性。注射后，有一定临床反应的患者收缩期峰值流速和舒张期最低流速较高，但只有舒张期流速的增加与临床反应程度呈逐步相关。该技术为客观评估体内注射罂粟碱的反应提供了一种方法。只有在确立正常值后，才能确定其作为诊断试验的潜力。目前，它在对罂粟碱注射反应不佳的患者中似乎最有用，可通过指出可能的血管损伤区域及进一步评估方向来发挥作用。
