Morana Giovanni, Shaw Dennis, MacDonald Shannon M, Alapetite Claire, Ajithkumar Thankamma, Bhatia Aashim, Brisse Hervé, Jaimes Camilo, Czech Thomas, Dhall Girish, Fangusaro Jason, Faure-Conter Cecile, Fouladi Maryam, Hargrave Darren, Harreld Julie H, Mitra Dipayan, Nicholson James C, Souweidane Mark, Timmermann Beate, Calaminus Gabriele, Bartels Ute, Bison Brigitte, Murray Matthew J
Department of Neurosciences, Neuroradiology Unit, University of Turin, Turin, Italy.
Department of Radiology, Seattle Children's Hospital and University of Washington, Seattle, WA, USA.
Lancet Oncol. 2022 May;23(5):e218-e228. doi: 10.1016/S1470-2045(22)00063-8.
Homogeneous and common objective disease assessments and standardised response criteria are important for better international clinical trials for CNS germ cell tumours. Currently, European protocols differ from those of North America (the USA and Canada) in terms of criteria to assess radiological disease response. An international working group of the European Society for Paediatric Oncology Brain Tumour Group and North American Children's Oncology Group was therefore established to review existing literature and current practices, identify major challenges regarding imaging assessment, and develop consensus recommendations for imaging response assessment for patients with CNS germ cell tumours. New clinical imaging standards were defined for the most common sites of CNS germ cell tumour and for the definition of locoregional extension. These new standards will allow the evaluation of response to therapy in patients with CNS germ cell tumours to be more consistent, and facilitate direct comparison of treatment outcomes across international studies.
同质化且通用的客观疾病评估以及标准化的反应标准对于开展更好的中枢神经系统生殖细胞肿瘤国际临床试验至关重要。目前，欧洲的方案在评估放射学疾病反应的标准方面与北美（美国和加拿大）不同。因此，欧洲儿科肿瘤学会脑肿瘤组和北美儿童肿瘤组成立了一个国际工作组，以回顾现有文献和当前实践，确定影像评估方面的主要挑战，并为中枢神经系统生殖细胞肿瘤患者的影像反应评估制定共识性建议。针对中枢神经系统生殖细胞肿瘤最常见部位以及局部区域扩展的定义制定了新的临床影像标准。这些新标准将使中枢神经系统生殖细胞肿瘤患者治疗反应的评估更加一致，并有助于国际研究之间直接比较治疗结果。
