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社交焦虑障碍发病年龄与精神健康结局的关系:基于全国代表性研究的结果。

Age of onset of social anxiety disorder and psychiatric and mental health outcomes: Results from a nationally representative study.

机构信息

Department of Child and Adolescent Psychiatry, Robert Debré Hospital, APHP, Paris, France; Neurodiderot, INSERM UMR 1141, Paris University, Paris, France; Laboratoire de Sciences Cognitives et Psycholinguistique (ENS, EHESS, CNRS), Ecole Normale Supérieure, PSL University, Paris, France.

Department of Child and Adolescent Psychiatry, Robert Debré Hospital, APHP, Paris, France.

出版信息

J Affect Disord. 2022 Jul 15;309:252-258. doi: 10.1016/j.jad.2022.04.149. Epub 2022 Apr 27.

Abstract

OBJECTIVE

Prior studies support that younger age of onset would be associated with poorer psychiatric and mental health outcomes for many psychiatric disorders. However, such relationship has never been examined for social anxiety disorder (SAD) in a nationally representative sample.

METHODS

Using data from the second Wave of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), we have identified four groups of participants with a lifetime DSM-IV diagnosis of SAD based on the self-reported age of onset (childhood onset (<12 years, N = 658), adolescence onset (12-17 years, N = 663), early-adulthood onset (18-39 years, N = 663), and late-adulthood onset (>39 years, N = 415)), and a control group without a lifetime history of SAD (N = 32,205). We performed multinomial logistic regression models to compare lifetime DSM-IV psychiatric disorders and current mental health-related quality of life (assessed with the mental component summary score (MSC) of the SF-12) across these groups.

RESULTS

The lifetime prevalence rates of panic disorder, agoraphobia and post-traumatic stress disorder were significantly higher in the adulthood onset groups than in groups with an onset during childhood or adolescence (p < 0.01 for most models). MCS score was significantly higher in the childhood (46.0 (SE = 0.5)) or adolescence (46.5 (SE = 0.5)) onset groups than in the groups with an onset during adulthood (early-adulthood onset: 43.5 (SE = 0.6), and late-adulthood onset: 43.0 (SE = 0.8)).

LIMITATIONS

Our results relied on retrospective self-reported data.

CONCLUSION

Among individuals with SAD, a later age of onset was significantly associated with greater lifetime rates of psychiatric disorders and diminished quality of life.

摘要

目的

先前的研究支持,对于许多精神疾病,发病年龄越小与较差的精神和心理健康结局相关。然而,在具有全国代表性的样本中,尚未对社交焦虑障碍(SAD)进行过这种关系的研究。

方法

使用来自第二次全国酒精相关情况和精神障碍流行病学调查(NESARC)的第二波数据,我们根据自我报告的发病年龄(儿童期发病(<12 岁,N=658)、青春期发病(12-17 岁,N=663)、成年早期发病(18-39 岁,N=663)和成年后期发病(>39 岁,N=415)),识别出了基于终生 DSM-IV 社交焦虑障碍诊断的四个参与者组,以及没有终生 SAD 病史的对照组(N=32205)。我们进行了多项逻辑回归模型分析,以比较这些组的终生 DSM-IV 精神障碍和当前与心理健康相关的生活质量(使用 SF-12 的心理成分综合得分(MSC)评估)。

结果

成年期发病组的惊恐障碍、广场恐惧症和创伤后应激障碍的终生患病率明显高于儿童期或青春期发病组(大多数模型的 p<0.01)。MSC 评分在儿童期(46.0(SE=0.5))或青春期(46.5(SE=0.5))发病组明显高于成年期发病组(成年早期发病组:43.5(SE=0.6),成年后期发病组:43.0(SE=0.8))。

局限性

我们的结果依赖于回顾性的自我报告数据。

结论

在患有 SAD 的个体中,发病年龄较晚与较高的终生精神障碍发生率和较差的生活质量显著相关。

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