紫檀中的化学成分及其对一氧化氮生成的抑制作用。
Chemical constituents from Pterocarpus santalinus and their inhibitory effects on nitric oxide production.
机构信息
College of Pharmacy, Chungbuk National University, Cheongju 28610, Republic of Korea.
College of Pharmacy, Chungbuk National University, Cheongju 28610, Republic of Korea.
出版信息
Fitoterapia. 2022 Jun;159:105202. doi: 10.1016/j.fitote.2022.105202. Epub 2022 Apr 28.
A tropolone (2) and an acorane sesquiterpene (3), along with twenty previously known compounds were isolated from the heartwood of Pterocarpus santalinus. The structure of the isolated compounds was elucidated via 1D and 2D NMR spectroscopy and HRESIMS analysis. The absolute configuration of 3 was determined by comparison of the experimental and calculated ECD data. All compounds were evaluated for their inhibitory effects against nitric oxide production in LPS-stimulated RAW 264.7 macrophages.
从紫檀的心材中分离得到一个紫檀烷（2）和一个阿科烷倍半萜（3），以及二十个已知化合物。通过 1D 和 2D NMR 光谱和 HRESIMS 分析阐明了分离化合物的结构。通过比较实验和计算的 ECD 数据确定了 3 的绝对构型。所有化合物均评估了其对 LPS 刺激的 RAW 264.7 巨噬细胞中一氧化氮产生的抑制作用。
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