School of Advanced Technology, Xi'an Jiaotong-Liverpool University, Suzhou 215123, China.
School of Advanced Technology, Xi'an Jiaotong-Liverpool University, Suzhou 215123, China.
J Biomed Inform. 2022 Jun;130:104078. doi: 10.1016/j.jbi.2022.104078. Epub 2022 Apr 27.
Scientific evidence shows that acoustic analysis could be an indicator for diagnosing COVID-19. From analyzing recorded breath sounds on smartphones, it is discovered that patients with COVID-19 have different patterns in both the time domain and frequency domain. These patterns are used in this paper to diagnose the infection of COVID-19. Statistics of the sound signals, analysis in the frequency domain, and Mel-Frequency Cepstral Coefficients (MFCCs) are then calculated and applied in two classifiers, k-Nearest Neighbors (kNN) and Convolutional Neural Network (CNN), to diagnose whether a user is contracted with COVID-19 or not. Test results show that, amazingly, an accuracy of over 97% could be achieved with a CNN classifier and more than 85% on kNN with optimized features. Optimization methods for selecting the best features and using various metrics to evaluate the performance are also demonstrated in this paper. Owing to the high accuracy of the CNN model, the CNN model was implemented in an Android app to diagnose COVID-19 with a probability to indicate the confidence level. The initial medical test shows a similar test result between the method proposed in this paper and the lateral flow method, which indicates that the proposed method is feasible and effective. Because of the use of breath sound and tested on the smartphone, this method could be used by everybody regardless of the availability of other medical resources, which could be a powerful tool for society to diagnose COVID-19.
科学证据表明,声学分析可能是诊断 COVID-19 的一个指标。通过分析智能手机上记录的呼吸声,发现 COVID-19 患者在时域和频域都有不同的模式。本文利用这些模式来诊断 COVID-19 感染。然后计算声音信号的统计数据、频域分析和梅尔频率倒谱系数(MFCC),并将其应用于两个分类器,k-最近邻(kNN)和卷积神经网络(CNN),以诊断用户是否感染了 COVID-19。测试结果表明,令人惊讶的是,CNN 分类器的准确率超过 97%,经过优化特征的 kNN 准确率超过 85%。本文还展示了用于选择最佳特征的优化方法以及使用各种指标来评估性能的方法。由于 CNN 模型的准确率很高,因此将 CNN 模型实现在 Android 应用程序中,以概率形式诊断 COVID-19 并指示置信度水平。初步的医学测试表明,本文提出的方法与侧向流动法之间的测试结果相似,这表明该方法是可行且有效的。由于该方法使用呼吸声并在智能手机上进行测试,因此无论其他医疗资源是否可用,每个人都可以使用该方法,这可能是社会诊断 COVID-19 的有力工具。