Juni K, Nakano M
Crit Rev Ther Drug Carrier Syst. 1987;3(3):209-32.
Poly(hydroxy acids) so far have been examined for use in drug delivery in limited number, while the advantageous use of the polymers has been recognized due to their biodegradability and biocompatibility. Homo- and copolymers of lactic acid and glycolic acid have been studied in drug delivery by many workers, while homo- and copolymers of epsilon-caprolactone have been studied by only one group of workers. Although poly-hydroxybutyric acid had been found to be a naturally occurring polymer, examination as to the use of the polymer in drug delivery is rather recent and reports are still limited. In the present article, the use of poly(hydroxy acids) including homo- and copolymers of lactic acid and glycolic acid, polycaprolactone, and poly-beta-hydroxybutyric acid in drug delivery is reviewed. Physicochemical properties, biodegradability, and biocompatibility of the polymers, and evaluations in vitro and in vivo of specific dosage forms using the polymers, are included. The most recent work in our laboratories on the use of polyactic acid and poly-beta-hydroxybutyric acid is also included.
到目前为止，对聚（羟基酸）在药物递送中的应用研究数量有限，不过由于其生物可降解性和生物相容性，人们已经认识到这些聚合物的优势用途。许多研究人员对乳酸和乙醇酸的均聚物和共聚物在药物递送方面进行了研究，而ε-己内酯的均聚物和共聚物仅由一组研究人员进行过研究。尽管聚-β-羟基丁酸已被发现是一种天然存在的聚合物，但对该聚合物在药物递送中的应用研究相当新，相关报道仍然有限。在本文中，对聚（羟基酸）在药物递送中的应用进行了综述，这些聚（羟基酸）包括乳酸和乙醇酸的均聚物和共聚物、聚己内酯以及聚-β-羟基丁酸。文中涵盖了这些聚合物的物理化学性质、生物可降解性和生物相容性，以及使用这些聚合物的特定剂型的体外和体内评价。还包括了我们实验室最近关于聚乳酸和聚-β-羟基丁酸应用的研究工作。
