Ferilli Michela Ada Noris, Papi Claudia, Sabatelli Mario, Colosimo Cesare, Iorio Raffaele
Neuroscience Department, Bambino Gesù Children's Hospital IRCCS, Rome, Italy; Neurology Unit, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
Neurology Unit, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy; Università Cattolica del Sacro Cuore, Rome, Italy.
J Neuroimmunol. 2022 Jun 15;367:577875. doi: 10.1016/j.jneuroim.2022.577875. Epub 2022 Apr 22.
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is an inflammatory syndrome characterized by the predominant involvement of the pons, the cerebellum and the spinal cord with a distinct corticosteroid responsiveness. To date, several cases of neurological disorders with a CLIPPERS-like phenotype have been described, including patients with Immunoglobulin G (IgG) antibodies binding to myelin oligodendrocyte glycoprotein (MOG). We herein report the case of a man with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) fulfilling the diagnostic criteria for probable CLIPPERS and a literature review of CLIPPERS-mimicking patients with MOG-IgG.
类固醇反应性桥脑周围血管增强的慢性淋巴细胞性炎症（CLIPPERS）是一种炎症综合征，其特征是桥脑、小脑和脊髓主要受累，且对皮质类固醇有明显反应。迄今为止，已描述了几例具有CLIPPERS样表型的神经疾病病例，包括免疫球蛋白G（IgG）抗体与髓鞘少突胶质细胞糖蛋白（MOG）结合的患者。我们在此报告一例符合可能CLIPPERS诊断标准的髓鞘少突胶质细胞糖蛋白抗体相关疾病（MOGAD）男性病例，并对具有MOG-IgG的CLIPPERS模拟患者进行文献综述。
